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Nucleotide sequence of the lantibiotic Pep5 biosynthetic gene cluster and functional analysis of PepP and PepC. Evidence for a role of PepC in thioether formation.
TLDR
It is demonstrated that PepC is a thioether-forming protein and strongly suggest that PepB is responsible for dehydration of serine and threonine in the cells without excretion of processed peptide.
Clostridium difficile infection in patients with neutropenia.
TLDR
Oral metronidazole can be recommended as initial drug of choice for treatment of patients with neutropenia who have hematologic malignancies and CDAD, indicating that C. difficile infection is not rare and should be suspected whenever a hospitalized patient with neutrupenia develops diarrhea.
Pseudomembranous and obstructive Aspergillus tracheobronchitis – optimal diagnostic strategy and outcome
TLDR
Bronchoscopic techniques were complementary in improving the yield of bronchoscopy but microscopy of mucous plugs and/or necrotic material was the best diagnostic modality, and prognosis of PMATB and OATB remains poor.
Is detection of bacterial DNA in ascitic fluid of clinical relevance?
TLDR
This study provides no evidence that detection of bacterial DNA in ascites of patients with liver cirrhosis is of clinical or diagnostic relevance when using the panel of LightCycler SeptiFast Kit Mgrade.
Breakthrough invasive fungal infections in neutropenic patients after prophylaxis with itraconazole
TLDR
It is demonstrated that patients with itraconazole trough concentrations below 500 ng ml−1 were significantly more likely to develop fungal infections and that the last itraconsole trough concentration before occurrence of the infection was significantly lower in patients with fatal invasiveFungal infections.
Evidence of MRSE on a gentamicin and vancomycin impregnated polymethyl-methacrylate (PMMA) bone cement spacer after two-stage exchange arthroplasty due to periprosthetic joint infection of the knee
TLDR
A case of a histologically confirmed chronic PJI 20 month after primary arthroplasty confirms for the first time the surface contamination (proven through sonication) of a vancomycin-/gentamicin- impregnated Vancogenx®-spacer with a MRSE after ten weeks of implantation.
Unyvero i60 implant and tissue infection (ITI) multiplex PCR system in diagnosing periprosthetic joint infection.
TLDR
Investigating the performance of the newly available Unyvero i60 implant and tissue infection (ITI) multiplex PCR System found it to be an additional - rapid - method for diagnosing PJI.
Successful Therapy of a Multidrug-Resistant Extended-Spectrum β-Lactamase-Producing and Fluoroquinolone-Resistant Salmonella enterica Subspecies enterica Serovar Typhi Infection Using Combination
TLDR
A traveler who acquired a Salmonella enterica subspecies enterica serovar Typhi strain with resistance against β-lactams, cephalosporins, and quinolones is reported, illustrating clinical challenges of multidrug-resistant S. Typhi.
Mode of action of the lantibiotic mersacidin: inhibition of peptidoglycan biosynthesis via a novel mechanism?
TLDR
Comparison with tunicamycin-treated cells indicated that peptidoglycan rather than teichoic acid metabolism is primarily affected, which suggests that mersacidin acts on a novel target, which opens new perspectives for the treatment of methicillin-resistant S. aureus.
Epidemiology, Prevention and Management of Ventriculoperitoneal Shunt Infections in Children
TLDR
The advent of ventriculoperitoneal shunts represented a substantial progress in the neurosurgical management of hydrocephalus in children and includes suggestions for the prevention, diagnosis and management of VPS infections.
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