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Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains
TLDR
A dramatic level of genome sequence complexity is revealed that may explain the differences that these strains exhibit in virulence and tissue tropism and suggests that wild-type virus carries more than 220 genes, some of which are lost by large-scale deletion and rearrangement of the UL/b' region during laboratory passage.
Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors
TLDR
Mouse cytomegalovirus encodes an MHC-like protein that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice, and this viral protein engages a related activating receptor and confers host protection.
A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2.
TLDR
Human cytomegalovirus (CMV), a herpesvirus that causes congenital disease and opportunistic infections in immunocompromised individuals, encodes functions that facilitate efficient viral propagation by altering host cell behavior and encodes a mitochondria-localized inhibitor of apoptosis, denoted vMIA, capable of suppressing apoptosis induced by diverse stimuli.
Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL*
TLDR
Two small molecule RIP3 kinase inhibitors are described and employ them to demonstrate the common requirement for RIP3 Kinase in programmed necrosis induced by RIP1-RIP3, DAI- RIP3, and TRIF-RIP 3 complexes.
RIP3 mediates the embryonic lethality of caspase-8-deficient mice
TLDR
It is found that RIP3 is responsible for the mid-gestational death of Casp8-deficient embryos and together completely dispensable for mammalian development.
Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis
TLDR
This book discusses pathogenesis, clinical disease, Host Response, and Epidemiology, as well as vaccines, immunotherapy, and other subjects related to infectious disease and epidemiology.
A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation
TLDR
A human cytomegalovirus cell-death suppressor, denoted vICA, encoded by the viral UL36 gene is identified, which inhibits Fas-mediated apoptosis by binding to the pro-domain of caspase-8 and preventing its activation.
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