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Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains
A dramatic level of genome sequence complexity is revealed that may explain the differences that these strains exhibit in virulence and tissue tropism and suggests that wild-type virus carries more than 220 genes, some of which are lost by large-scale deletion and rearrangement of the UL/b' region during laboratory passage.
Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors
Mouse cytomegalovirus encodes an MHC-like protein that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice, and this viral protein engages a related activating receptor and confers host protection.
A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2.
- V. Goldmacher, L. Bartle, T. Chittenden
- BiologyProceedings of the National Academy of Sciences…
- 26 October 1999
Human cytomegalovirus (CMV), a herpesvirus that causes congenital disease and opportunistic infections in immunocompromised individuals, encodes functions that facilitate efficient viral propagation by altering host cell behavior and encodes a mitochondria-localized inhibitor of apoptosis, denoted vMIA, capable of suppressing apoptosis induced by diverse stimuli.
Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL*
Two small molecule RIP3 kinase inhibitors are described and employ them to demonstrate the common requirement for RIP3 Kinase in programmed necrosis induced by RIP1-RIP3, DAI- RIP3, and TRIF-RIP 3 complexes.
RIP3 mediates the embryonic lethality of caspase-8-deficient mice
It is found that RIP3 is responsible for the mid-gestational death of Casp8-deficient embryos and together completely dispensable for mammalian development.
Virus inhibition of RIP3-dependent necrosis.
Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis
This book discusses pathogenesis, clinical disease, Host Response, and Epidemiology, as well as vaccines, immunotherapy, and other subjects related to infectious disease and epidemiology.
RIP3 induces apoptosis independent of pronecrotic kinase activity.
DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.
A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation
- A. Skaletskaya, L. Bartle, T. Chittenden, A. McCormick, E. Mocarski, V. Goldmacher
- Biology, MedicineProceedings of the National Academy of Sciences…
- 26 June 2001
A human cytomegalovirus cell-death suppressor, denoted vICA, encoded by the viral UL36 gene is identified, which inhibits Fas-mediated apoptosis by binding to the pro-domain of caspase-8 and preventing its activation.