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The ID23-1 structural biology beamline at the ESRF.
The ESRF has constructed a dual station beamline using a canted undulator system as the X-ray source and a new software suite has been developed to permit reliable easy operation for the beamline users and beamline staff.
The ID23-2 structural biology microfocus beamline at the ESRF
Beamline ID23-2, the first dedicated and highly automated high-throughput monochromatic macromolecular crystallography microfocus beamline, is described.
Crystal structure of Spa40, the specificity switch for the Shigella flexneri type III secretion system
- J. E. Deane, S. C. Graham, E. Mitchell, D. Flot, Steven Johnson, S. Lea
- BiologyMolecular microbiology
- 29 May 2008
It is shown that Spa40 is cleaved within the strictly conserved amino acid sequence NPTH and substitution of the proposed autocatalytic residue abolishes cleavage, suggesting a mechanism by which non‐cleaving forms of these proteins interfere with correct substrate switching of the apparatus.
The nature of the di-iron site in the bacterioferritin from Desulfovibrio desulfuricans
Molecular surface and electrostatic potential calculations suggest the presence of another ion channel, distant from the channels at the three- and four-fold axes proposed as points of entry for the iron atoms.
A Structural Study of Norovirus 3C Protease Specificity: Binding of a Designed Active Site-Directed Peptide Inhibitor†
The X-ray structure of the Southampton norovirus 3C protease (SV3CP) bound to an active site-directed peptide inhibitor (MAPI) which has been refined at 1.7 Å resolution provides important new information for the development of antiviral prophylactics.
Structures of the lectins from Pseudomonas aeruginosa: insight into the molecular basis for host glycan recognition.
Beta-propeller crystal structure of Psathyrella velutina lectin: an integrin-like fungal protein interacting with monosaccharides and calcium.
Crystal Structure of Fungal Lectin
- M. Wimmerová, E. Mitchell, Jean-Frédéric Sanchez, C. Gautier, A. Imberty
- Chemistry, BiologyJournal of Biological Chemistry
- 18 July 2003
This multivalent carbohydrate recognition fold is a new prototype of lectins that is proposed to be involved in the host recognition strategy of several pathogenic organisms including not only the fungi Aspergillus but also the phytopathogenic bacterium Ralstonia solanacearum.
Biochemical and Structural Analysis of Helix pomatia Agglutinin
- Jean-Frédéric Sanchez, J. Lescar, E. Mitchell
- Biology, ChemistryJournal of Biological Chemistry
- 21 July 2006
The peptide sequence deduced from gene cloning demonstrates that HPA belongs to a family of carbohydrate-binding proteins recently identified in several invertebrates and rationalizes the observed preference for αGalNAc-containing oligosaccharides.
Glycerol concentrations required for cryoprotection of 50 typical protein crystallization solutions
A determination has been made of the glycerol concentration required to form an amorphous glass at 100 K with each of the 50 Crystal Screen I Solutions (Hampton Research, Laguna Hills, California,…