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- Publications
- Influence
Lack of effect of induction of hypothermia after acute brain injury.
- G. Clifton, E. Miller, +9 authors M. Schwartz
- Medicine
- The New England journal of medicine
- 22 February 2001
BACKGROUND
Induction of hypothermia in patients with brain injury was shown to improve outcomes in small clinical studies, but the results were not definitive. To study this issue, we conducted a… Expand
Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease.
- S. Tsimikas, E. Brilakis, +5 authors P. Berger
- Medicine
- The New England journal of medicine
- 7 July 2005
BACKGROUND
Lp(a) lipoprotein binds proinflammatory oxidized phospholipids. We investigated whether levels of oxidized low-density lipoprotein (LDL) measured with use of monoclonal antibody E06… Expand
Vascular Lipid Accumulation, Lipoprotein Oxidation, and Macrophage Lipid Uptake in Hypercholesterolemic Zebrafish
- K. Stoletov, L. Fang, +11 authors Y. Miller
- Biology, Medicine
- Circulation research
- 24 April 2009
Lipid accumulation in arteries induces vascular inflammation and atherosclerosis, the major cause of heart attack and stroke in humans. Extreme hyperlipidemia induced in mice and rabbits enables… Expand
Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes.
- S. Tsimikas, C. Bergmark, +5 authors J. Witztum
- Medicine
- Journal of the American College of Cardiology
- 5 February 2003
OBJECTIVES
This study was conducted to test the hypothesis that plasma markers of oxidized low-density lipoprotein (OxLDL) reflect acute coronary syndromes (ACS).
BACKGROUND
Oxidized LDL… Expand
Conventional Dendritic Cells at the Crossroads Between Immunity and Cholesterol Homeostasis in Atherosclerosis
- E. Gautier, T. Huby, +8 authors P. Lesnik
- Biology, Medicine
- Circulation
- 5 May 2009
Background— Immunoinflammatory mechanisms are implicated in the atherogenic process. The polarization of the immune response and the nature of the immune cells involved, however, are major… Expand
Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events Published, JLR Papers in Press, November 8, 2006.
- S. Tsimikas, E. Brilakis, +5 authors P. Berger
- Medicine
- Journal of Lipid Research
- 1 February 2007
The relationship between autoantibodies to oxidized low density lipoprotein (OxLDL) and coronary artery disease (CAD) remains controversial. IgM and IgG OxLDL autoantibodies to malondialdehyde… Expand
Relationship of IgG and IgM autoantibodies and immune complexes to oxidized LDL with markers of oxidation and inflammation and cardiovascular events: results from the EPIC-Norfolk Study
- A. Ravandi, S. Boekholdt, +9 authors S. Tsimikas
- Medicine
- Journal of Lipid Research
- 1 October 2011
Levels of IgG and IgM autoantibodies (AA) to malondialdehyde (MDA)-LDL and apoB-immune complexes (ICs) were measured in 748 cases and 1,723 controls in the EPIC-Norfolk cohort and their association… Expand
Local Expression of Platelet-Activating Factor-Acetylhydrolase Reduces Accumulation of Oxidized Lipoproteins and Inhibits Inflammation, Shear Stress-Induced Thrombosis, and Neointima Formation in…
- H. Arakawa, Jian-Yong Qian, +6 authors H. Ueno
- Medicine
- Circulation
- 21 June 2005
Background—Platelet-activating factor (PAF) and PAF-like phospholipids are inactivated by PAF-acetylhydrolase (PAF-AH). Using nonhyperlipidemic animals, we tested whether local expression of PAF-AH… Expand
Oxidized phospholipids are present on plasminogen, affect fibrinolysis, and increase following acute myocardial infarction.
- G. Leibundgut, Kiyohito Arai, +7 authors S. Tsimikas
- Medicine
- Journal of the American College of Cardiology
- 17 April 2012
OBJECTIVES
This study sought to assess whether plasminogen, which is homologous to lipoprotein (a) [Lp(a)], contains proinflammatory oxidized phospholipids (OxPL) and whether this has clinical… Expand
Oxidized low-density lipoprotein autoantibodies, chronic infections, and carotid atherosclerosis in a population-based study.
- M. Mayr, S. Kiechl, +5 authors Q. Xu
- Medicine
- Journal of the American College of Cardiology
- 20 June 2006
OBJECTIVES
We investigated whether associations exist between immune reactions to oxidized low-density lipoproteins (OxLDLs), chronic infections, and carotid atherosclerosis as quantified by… Expand