• Publications
  • Influence
The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.
TLDR
Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing. Expand
Allergy, principles and practice
Volume 1: immunology biology of eosinophils pathophysiology of allergic inflammation physiology pharmacology principles of therapeutics theophylline antihistamines cromolyn and nedocromilExpand
Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships.
TLDR
Analysis of structure-activity data revealed a model of the minimal essential features required for PKC inhibition by flavonoids: a coplanar flavone structure with free hydroxyl substituents at the 3', 4' and 7-positions. Expand
Effect of plant flavonoids on immune and inflammatory cell function.
  • E. Middleton
  • Chemistry, Medicine
  • Advances in experimental medicine and biology
  • 1998
TLDR
A considerable body of evidence suggests that plant flavonoids may be health-promoting, disease-preventing dietary compounds. Expand
Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis‐associated properties in A431 cells overexpressing epidermal growth factor receptor
TLDR
Examination of the relationship between the chemical structure and inhibitory effects of eight flavonoids reveal that the double bond between C2 and C3 in ring C and the OH groups on C3′ and C4′ in ring B are critical for the biological activities. Expand
Effects of flavonoids on immune and inflammatory cell functions.
TLDR
Evidence indicates that selected flavonoids, depending on structure, can affect (usually inhibit) secretory processes, mitogenesis, and cell-cell interactions including possible effects on adhesion molecule expression and function and a potential mechanism of action that requires scrutiny is the redox activity of appropriately configured flavonoid. Expand
Middleton's Allergy: Principles and Practice
TLDR
This new edition includes 700 full-color illustrations and a new, more accessible format to make finding information a snap for the busy practitioner and online access to the complete contents of the 2-volume set, fully searchable, and much more. Expand
Allergy-related diseases and cancer: an inverse association.
TLDR
The findings suggest that individuals with allergy-related disorders may be at decreased risk of cancer, although reasons for cautious interpretation of the findings are emphasized. Expand
The development of respiratory syncytial virus-specific IgE and the release of histamine in nasopharyngeal secretions after infection.
TLDR
Formation of RSV-specific IgE and release of histamine may adversely affect the outcome ofRSV infection and is correlated significantly with the degree of hypoxia. Expand
Evaluation of dose-related pharmacokinetics and pharmacodynamics of prednisolone in man
TLDR
This study comprehensively elucidates the complexities of prednisolone pharmacokinetics and demonstrates how plasma concentration-time profiles of total or free prednisOLone can be utilized for evaluation of predisonsolone Pharmacodynamics. Expand
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