The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.
- E. Middleton, C. Kandaswami, T. Theoharides
- Chemistry, MedicinePharmacological Reviews
- 1 December 2000
Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing.
Allergy, principles and practice
- E. Middleton, C. Reed, E. Ellis
- Medicine, Biology
Volume 1: immunology biology of eosinophils pathophysiology of allergic inflammation physiology pharmacology principles of therapeutics theophylline antihistamines cromolyn and nedocromil…
Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships.
- P. Ferriola, V. Cody, E. Middleton
- Chemistry, BiologyBiochemical Pharmacology
- 15 May 1989
Effect of plant flavonoids on immune and inflammatory cell function.
- E. Middleton
- BiologyAdvances in Experimental Medicine and Biology
A considerable body of evidence suggests that plant flavonoids may be health-promoting, disease-preventing dietary compounds.
Antiviral effect of flavonoids on human viruses
- T. Kaul, E. Middleton, P. Ogra
- BiologyJournal of Medical Virology
- 1 January 1985
The effect of several naturally occurring dietary flavonoids including quercetin, naringin, hesperetin, and catechin on the infectivity and replication of herpes simplex virus type 1 (HSV‐I),…
Middleton's Allergy: Principles and Practice
- N. Adkinson, E. Middleton
- 18 September 2013
This new edition includes 700 full-color illustrations and a new, more accessible format to make finding information a snap for the busy practitioner and online access to the complete contents of the 2-volume set, fully searchable, and much more.
Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis‐associated properties in A431 cells overexpressing epidermal growth factor receptor
- Y. ‐. Huang, J. Hwang, M. ‐. Lee
- BiologyBritish Journal of Pharmacology
- 1 November 1999
Examination of the relationship between the chemical structure and inhibitory effects of eight flavonoids reveal that the double bond between C2 and C3 in ring C and the OH groups on C3′ and C4′ in ring B are critical for the biological activities.
Effects of flavonoids on immune and inflammatory cell functions.
- E. Middleton, C. Kandaswami
- BiologyBiochemical Pharmacology
- 17 March 1992
Allergy-related diseases and cancer: an inverse association.
- J. Vena, J. Bona, T. Byers, E. Middleton, M. Swanson, S. Graham
- MedicineAmerican Journal of Epidemiology
- 1 July 1985
The findings suggest that individuals with allergy-related disorders may be at decreased risk of cancer, although reasons for cautious interpretation of the findings are emphasized.
The development of respiratory syncytial virus-specific IgE and the release of histamine in nasopharyngeal secretions after infection.
- R. Welliver, D. Wong, M. Sun, E. Middleton, R. Vaughan, P. Ogra
- Medicine, BiologyNew England Journal of Medicine
- 8 October 1981
Formation of RSV-specific IgE and release of histamine may adversely affect the outcome ofRSV infection and is correlated significantly with the degree of hypoxia.