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Isoflavonoids – an overview of their biological activities and potential health benefits
  • E. Miadoková
  • Medicine
    Interdisciplinary toxicology
  • 1 December 2009
The results of epidemiologic studies exploring the role of isoflavonoids in human health have been inconclusive; some studies support the notion of a protective effect of their consumption in immunomodulation, cognition, risk reduction of certain cancers, cardiovascular and skin diseases, osteoporosis and obesity, as well as relief of menopausal symptoms.
Yeast cell wall polysaccharides as antioxidants and antimutagens: can they fight cancer?
The results indicate significant protective antioxidant, antimutagenic, and antigenotoxic activities of the yeast polysaccharides and imply their potential application in anticancer prevention/therapy.
Generation of a set of conditional analog-sensitive alleles of essential protein kinases in the fission yeast Schizosaccharomyces pombe
To inactivate these kinases conditionally, the mutation of a single residue in the ATP-binding pocket confers sensitivity to small-molecule inhibitors, allowing for specific inactivation of the modified kinase.
Dual activity of triterpenoids: apoptotic versus antidifferentiation effects
It is suggested that although triterpenoids UA and OA can induce apoptosis, their antioxidant activities can interfere with the therapeutic effect of antitumor antibiotic Dox which mechanism of action is attributed to the production of reactive oxygen species.
Silver nanoparticles induce premutagenic DNA oxidation that can be prevented by phytochemicals from Gentiana asclepiadea.
It is shown that AgNPs (20 nm) are taken up by cells and localised in vacuoles and cytoplasm and that oxidative damage to DNA in human kidney HEK 293 cells was diminished by aqueous and methanolic extracts from both haulm and flower of Gentiana asclepiadea.
Chlamydomonas reinhardtii: a convenient model system for the study of DNA repair in photoautotrophic eukaryotes
Comparing the results of repair investigations that are already available revealed the presence of all basic repair pathways in C. reinhardtii as well as special features characteristic of this alga, which will be a basis for molecular analyses allowing to explain the differences that have been observed in DNA repair of thisAlga in comparison with other model organisms.
Antigenotoxic effect of extract from Cynara cardunculus L.
It is concluded that CCE is of particular interest as a suitable candidate for an effective chemopreventive agent as well as an antigenotoxic and antioxidant agent.
Gentiana asclepiadea protects human cells against oxidation DNA lesions
Results suggest that the tested G. asclepiadea extracts could be considered as an effective natural antioxidant source.
Growth inhibitory effect of ethyl acetate‐soluble fraction of Cynara cardunculus L. in leukemia cells involves cell cycle arrest, cytochrome c release and activation of caspases
The results suggest that CCE exerts an antiproliferative activity on leukemia cells and induces apoptosis of these cells through a mitochondrial/caspase dependent pathway.