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Recombinant maxi-K channels on transistor, a prototype of iono-electronic interfacing
We report on the direct electrical interfacing of a recombinant ion channel to a field-effect transistor on a silicon chip. The ion current through activated maxi-KCa channels in human embryonicExpand
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Cable Properties of Dendrites in Hippocampal Neurons of the Rat Mapped by a Voltage‐sensitive Dye
Dendrites of pyramidal neurons from embryonic rat hippocampus are investigated in culture using a voltage‐sensitive fluorescent dye. The electrical response to somatic stimulation is observed as aExpand
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Ca2+ activation of hSlo K+ channel is suppressed by N‐terminal GFP tag
The human slow poke (hSlo) K+ channel was tagged with GFP (green fluorescent protein) at the N‐terminus of its α‐subunit. The fusion protein was expressed transiently in HEK293 cells; it formedExpand
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Sedation and Need-Free Salt Intake in Rats Treated With Clonidine
The effect of intraperitoneal injection of clonidine (9-72 microg/kg) on need-free 1.5% NaCl intake and on performance (defined as percent of a complete trial) in the rotarod test, was studied inExpand
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Transdermal delivery using a novel electrochemical device, part 2: in vivo study in humans.
A single-center, open-label, and dose-escalation clinical trial has been performed using a novel electrochemical transdermal patch comprising a drug-loaded hydrogel sandwiched between two silverExpand
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Functional proteomics using chromophore‐ assisted laser inactivation
Proteins are the molecules that fulfil most cellular functions and represent over 90% of drug targets in the market. Chromophore‐assisted laser inactivation (CALI) provides a timely and locallyExpand
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Transdermal delivery using a novel electrochemical device, part 1: device design and in vitro release/permeation of fentanyl.
A new type of electrochemical transdermal patch has been investigated using release/permeation experiments with excised nude mouse skin. The patch comprises a drug-containing hydrogel sandwichedExpand
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New inhibitors of Mycobacterium tuberculosis identified using systems chemical biology
With the rise in antibiotic resistance, new drugs are desperately needed against Mycobacterium tuberculosis (Mtb). Combining chemistry and genetics, we developed a new strategy for rapidlyExpand
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Ca 2 1 activation of hSlo K 1 channel is suppressed by N-terminal GFP tag
The human slow poke (hSlo) K1 channel was tagged with GFP (green fluorescent protein) at the N-terminus of its α-subunit. The fusion protein was expressed transiently in HEK293 cells; it formedExpand
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