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Autologous stem cell transplantation for progressive multiple sclerosis: Update of the European Group for Blood and Marrow Transplantation autoimmune diseases working party database
HSCT was shown as a promising procedure to slow down progression in a subset of patients affected by severe, progressive MS; the safety and feasibility of the procedure can be significantly improved by appropriate patient selection and choice of transplant regimen.
Clinical characteristics, course and prognosis of relapsing Devic’s Neuromyelitis Optica
Compared with MS, DNO patients have a higher age at onset, females are more frequently affected, the course is more severe and DNO has a poor prognosis in most cases.
Autologous haematopoietic stem cell transplantation with an intermediate intensity conditioning regimen in multiple sclerosis: the Italian multi-centre experience
This study shows that AHSCT with a BEAM/ATG conditioning regimen has a sustained effect in suppressing disease progression in aggressive MS cases unresponsive to conventional therapies and can also cause a sustained clinical improvement, especially if treated subjects are still in the relapsing–remitting phase of the disease.
Three cases of human herpesvirus‐6 latent infection: Integration of viral genome in peripheral blood mononuclear cell DNA
The study showed the presence of intact viral genome, of the expected length of 170 kb, persisting as free extrachromosomal element in the HSB‐2 cells but not in patients' peripheral blood mononuclear cells, indicating that the viral sequences are linked to high molecular weight cellular DNA.
Targeted integration of human herpesvirus 6 in the p arm of chromosome 17 of human peripheral blood mononuclear cells in vivo
A further study of the same patients with chromo some fluorescence in situ hybridization showed the presence of a specific hybridization site, located at the telomeric extremity of the short arm of chromosome 17 (17p13), suggesting that this location is at least a preferred site of an infrequent, but biologically important, integration phenomenon.
Autologous hematopoietic stem cell transplantation in multiple sclerosis
Intense immunosuppression followed by AHSCT is significantly superior to MTX in reducing MRI activity in severe cases of MS, and these results strongly support further phase III studies with primary clinical endpoints.
Psychiatric disorders and depression in multiple sclerosis outpatients: impact of disability and interferon beta therapy
Associations between psychopathology and gender, duration of MS, disability and therapy with beta-interferons were studied in multiple sclerosis outpatients, finding disability level, but not therapy with interferon beta or longer duration of illness, is a risk factor for depression in MS outpat patients.
Human herpesvirus 6 and multiple sclerosis: survey of anti-HHV-6 antibodies by immunofluorescence analysis and of viral sequences by polymerase chain reaction.
- P. Sola, E. Merelli, +4 authors G. Torelli
- MedicineJournal of neurology, neurosurgery, and…
- 1 August 1993
Since viral sequences are rarely present in MS subjects, the high anti-HHV-6 antibody titres found in MS are likely to be related to immune impairment rather than reactivation of a latent infection.
Human herpes virus 6 and human herpes virus 8 DNA sequences in brains of multiple sclerosis patients, normal adults and children
Data do not support a hypothesis that there is a role for these two HHVs in the pathogenesis of MS, nevertheless it may be suggested that (1) the two viruses possess strong neurotropism and the central nervous system seems to be a reservoir for them (2) HHV-6 infection is probably not transmitted maternally, but is acquired later in infancy.
Epidemiological survey of multiple sclerosis in the provinces of Reggio Emilia and Modena, Italy.
This study is a further demonstration that Italy is a high-risk zone for this disease, and also demonstrates the possibility of carrying out reliable epidemiological surveys even over extensive territories.