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Chylothorax: aetiology, diagnosis and therapeutic options.
Chylothorax is a rare condition that results from thoracic duct damage with chyle leakage from the lymphatic system into the pleural space, usually on the right side. It has multiple aetiologies and… Expand
Diagnosis of pleural effusion: a systematic approach.
In most diseases related to pleural effusion, the fluid analysis yields important diagnostic information, and in certain cases, fluid analysis alone is enough for diagnosis. The many important… Expand
TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation
- E. Mcgrath, H. Marriott, +5 authors M. Whyte
- Biology, Medicine
- Journal of leukocyte biology
- 1 November 2011
Novel therapeutics targeting neutrophilic inflammation are a major unmet clinical need in acute and chronic inflammation. The timely induction of neutrophil apoptosis is critical for inflammation… Expand
The Toll-like receptor 3 L412F polymorphism and disease progression in idiopathic pulmonary fibrosis.
- D. O'Dwyer, M. Armstrong, +10 authors S. Donnelly
- American journal of respiratory and critical care…
- 14 December 2013
RATIONALE Idiopathic pulmonary fibrosis (IPF) is a fatal progressive interstitial pneumonia. The innate immune system provides a crucial function in the recognition of tissue injury and infection.… Expand
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.
Neutrophil lifespan and function are regulated by hypoxia via components of the hypoxia inducible factor (HIF)/von Hippel Lindau/hydroxylase pathway, including specific roles for HIF-1α and prolyl… Expand
Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis
Background The death receptor ligand tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) shows considerable clinical promise as a therapeutic agent. TRAIL induces leukocyte apoptosis,… Expand
Twenty years of SHIELD: decreasing incidence of occupational asthma in the West Midlands, UK?
- G. Walters, A. Kirkham, E. Mcgrath, V. Moore, A. Robertson, P. Burge
- Occupational and Environmental Medicine
- 21 January 2015
Introduction Since 2000 a decline in the incidence of occupational asthma (OA) has been reported in the UK and Europe. We aimed to describe and account for trends in the incidence of OA in the West… Expand
Black hairy tongue: What is your call?
- E. Mcgrath, P. Bardsley, Gurnan Basran
- Medicine, Biology
- Canadian Medical Association Journal
- 22 April 2008
A 73-year-old male smoker attended a follow-up outpatient clinic 18 months after starting antibiotic therapy (rifampicin, isoniazid and clarithromycin) for a nontuberculous mycobacterial lung… Expand
The tumor necrosis factor-related apoptosis-inducing ligand and lung cancer: still following the right TRAIL?
- E. Mcgrath
- Journal of thoracic oncology : official…
- 1 June 2011
Tumor necrosis factor-related apoptosis-inducing ligand is a type II membrane-bound protein whose C-terminal extracellular domain shows clear homology to other tumor necrosis factor family members.… Expand
Nontuberculous Mycobacteria and the Lung: From Suspicion to Treatment
Nontuberculous mycobacteria (NTM) are resilient bacteria that grow in virtually any environment, especially those where competing microorganisms are destroyed, such as in chlorinated water. They have… Expand