• Publications
  • Influence
T cell exhaustion, costimulation and clinical outcome in autoimmunity and infection
TLDR
A transcriptional signature reflecting CD8 T-cell exhaustion is associated with poor clearance of chronic viral infection, but conversely predicts better prognosis in multiple autoimmune diseases, suggesting that each process plays a role in dictating outcome in autoimmune disease.
A CD8 T cell transcription signature predicts prognosis in autoimmune disease
TLDR
It is shown that transcriptional profiling of purified CD8+ T cells, which avoids the confounding influences of unseparated cells, identifies two distinct subject subgroups predicting long-term prognosis in two autoimmune diseases, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and systemic lupus erythematosus (SLE).
Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis.
TLDR
Using transcriptional profiling of circulating T cells isolated from patients with CD and UC, this work identifies what it believes to be the first biomarker that can predict prognosis in both UC and CD from diagnosis, a major step toward personalized therapy.
Association between polymorphisms in dopamine metabolic enzymes and tobacco consumption in smokers.
TLDR
The view that these enzymes help to determine a smoker's requirement for nicotine and may explain why some people are predisposed to tobacco addiction and why some find it very difficult to stop smoking is supported.
DONOR CYTOKINE GENOTYPE INFLUENCES THE DEVELOPMENT OF ACUTE REJECTION AFTER RENAL TRANSPLANTATION
TLDR
Evidence is provided that donor-derived cytokines play a major role in determining outcome after transplantation, and will contribute to the development of therapeutic algorithms to predict individuals at particularly high risk of acute rejection.
High prevalence of autoantibodies to hLAMP-2 in anti-neutrophil cytoplasmic antibody-associated vasculitis.
  • R. Kain, H. Tadema, A. Rees
  • Biology, Medicine
    Journal of the American Society of Nephrology…
  • 1 March 2012
The involvement of autoantibodies to human lysosome-associated membrane protein-2 (hLAMP-2) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is controversial because of the
Novel expression signatures identified by transcriptional analysis of separated leucocyte subsets in systemic lupus erythematosus and vasculitis
TLDR
Analysis of leucocyte subsets enabled the identification of gene signatures of both pathogenic relevance and with better disease discrimination than those identified in PBMC, providing substantial advantages in the search for diagnostic and prognostic biomarkers in autoimmune disease.
From Big Data to Precision Medicine
TLDR
Both the opportunities and challenges posed to biomedical research by the increasing ability to tackle large datasets are discussed, including the need for standardization of data content, format, and clinical definitions.
A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes
Diagnosis of the autoimmune disease type 1 diabetes (T1D) is preceded by the appearance of circulating autoantibodies to pancreatic islets. However, almost nothing is known about events leading to
The immunopathology of ANCA-associated vasculitis
TLDR
Advances in the understanding of the pathogenesis of the syndromes have been accompanied by some progress in treatment, although much remains to be done to improve the chronic morbidity associated with the immunosuppression required for disease control.
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