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Gut feelings: the emerging biology of gut–brain communication
- E. Mayer
- Biology, Medicine
- Nature Reviews Neuroscience
- 13 July 2011
A complex, bidirectional communication system that not only ensures the proper maintenance of gastrointestinal homeostasis and digestion but is likely to have multiple effects on affect, motivation and higher cognitive functions, including intuitive decision making is revealed. Expand
Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
It is found that a large proportion of primary spinal afferent neurons also contain the proinflammatory neuropeptides calcitonin gene-related peptide and substance P, which mediate inflammatory edema induced by agonists of proteinase-activated receptor 2. Expand
AGA technical review on irritable bowel syndrome.
Psychosocial factors, although not part of IBS per se, have an important role in modulating the illness experience and its clinical outcome. Expand
Altered rectal perception is a biological marker of patients with irritable bowel syndrome.
Because altered rectal perception is present in almost all patients with IBS and perception thresholds correlate with temporal changes in retrospective symptom severity, altered Rectal perception represents a reliable biological marker of IBS. Expand
Psychometric Properties of the Early Trauma Inventory–Self Report
- J. Bremner, R. Bolus, E. Mayer
- Psychology, Medicine
- The Journal of nervous and mental disease
- 1 March 2007
It is suggested that the ETI-SR is a valid measure of early trauma, and future directions for a shortened version of the ETi-SR that could be more easily incorporated into clinical research studies and practice settings are suggested. Expand
Protease-Activated Receptor 2 Sensitizes the Capsaicin Receptor Transient Receptor Potential Vanilloid Receptor 1 to Induce Hyperalgesia
A novel mechanism by which proteases that activate PAR2 sensitize TRPV1 through PKC is identified, which may abrogate protease-induced thermal hyperalgesia. Expand
Principles and clinical implications of the brain–gut–enteric microbiota axis
- S. Rhee, C. Pothoulakis, E. Mayer
- Biology, Medicine
- Nature Reviews Gastroenterology &Hepatology
- 1 May 2009
Enterochromaffin cells are important bidirectional transducers that regulate communication between the gut lumen and the nervous system, and may have an important role in pain and immune-response modulation, control of background emotions and other homeostatic functions. Expand
Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat.
- S. V. Coutinho, P. Plotsky, +5 authors E. Mayer
- American journal of physiology. Gastrointestinal…
- 1 February 2002
It is suggested that early life events predispose adult Long-Evans rats to develop visceral hyperalgesia, reduced somatic analgesia, and increased colonic motility in response to an acute psychological stressor, mimicking the cardinal features of irritable bowel syndrome. Expand
One-year test–retest reliability of intrinsic connectivity network fMRI in older adults
This study provides a direct comparison between the most commonly used ICN fMRI methods and potential guidelines for measuring intrinsic connectivity in aging control and patient populations over time. Expand
Consumption of fermented milk product with probiotic modulates brain activity.
Alterations in intrinsic activity of resting brain indicated that ingestion of FMPP was associated with changes in midbrain connectivity, which could explain the observed differences in activity during the task. Expand