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Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL).
Criteria for the immunological classification of acute leukemias are proposed by a recently established European group designated EGIL. The main aims of EGIL are to establish guidelines for the… Expand
The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL.
We have investigated the role of immunophenotyping in distinguishing between leukemic B-cell lymphoproliferative disorders. Circulating cells from 666 cases were analyzed with a panel of markers by… Expand
A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease.
We analyzed lymphocyte morphology, histology, immunophenotype, immunoglobulin heavy chain (IgVH) gene mutations, and clinical course in 80 unselected patients presenting with circulating t(11;14)… Expand
Outcome of biphenotypic acute leukemia.
BACKGROUND AND OBJECTIVE Although biphenotypic leukemia is now a defined entity, outcome of this rare form of acute leukemia has not been well documented. We present the first comprehensive study… Expand
Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b).
- E J Moreau, E. Matutes, +5 authors D. Catovsky
- American journal of clinical pathology
- 1 October 1997
A scoring system, based on the immunophenotypic analysis of a panel of five membrane markers (CD5, CD22, CD23, FMC7, SmIg) was shown to be useful in the distinction between chronic lymphocytic… Expand
Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial
- D. Catovsky, S. Richards, E. Matutes, D. Oscier, Ncri Chronic Lymphocytic Leukaemia Working Group
- The Lancet
- 21 July 2007
BACKGROUND Previous studies of patients with chronic lymphocytic leukaemia reported high response rates to fludarabine combined with cyclophosphamide. We aimed to establish whether this treatment… Expand
Levels of expression of CD19 and CD20 in chronic B cell leukaemias.
- L. Ginaldi, M. De Martinis, E. Matutes, N. Farahat, R. Morilla, D. Catovsky
- Biology, Medicine
- Journal of clinical pathology
- 1 May 1998
AIMS: To investigate whether the antigen levels of the B cell lineage markers CD19 and CD20 can distinguish between normal and neoplastic B cells or characterise distinct expression patterns among… Expand
Definition of acute biphenotypic leukemia.
BACKGROUND AND OBJECTIVE A minority of acute leukemias have features characteristic of both the myeloid and lymphoid lineages and for this reason are designated mixed-lineage, hybrid or biphenotypic… Expand
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia
- Maria Chiara Di Bernardo, Dalemari Crowther-Swanepoel, +26 authors R. Houlston
- Biology, Medicine
- Nature Genetics
- 1 October 2008
We conducted a genome-wide association study of 299,983 tagging SNPs for chronic lymphocytic leukemia (CLL) and performed validation in two additional series totaling 1,529 cases and 3,115 controls.… Expand
High remission rate in T-cell prolymphocytic leukemia with CAMPATH-1H.
T-cell prolymphocytic leukemia (T-PLL) is a chemotherapy-resistant malignancy with a median survival of 7.5 months. Preliminary results indicated a high remission induction rate with the human CD52… Expand