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Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors
Experimental data is summarized that outline how the discovery that NO modulates prostaglandin production has impacted and extended the understanding of these two systems in physiopathological events.
A Newly Identified Role for Superoxide in Inflammatory Pain
A critical role for superoxide is unraveled in the nociceptive signaling cascade both peripherally and centrally and the discovery of this pathway opens a new therapeutic strategy for the development of novel nonnarcotic antihyperalgesic agents.
A role for superoxide in gentamicin-mediated nephropathy in rats.
Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P.
Data indicate that NO production induced by vasoactive agents, such as SP, functions as an autocrine regulator of the microvascular events necessary for neovascularization and mediates angiogenesis.
The Role of Cyclooxygenase-2 in Mediating the Effects of Histamine on Cell Proliferation and Vascular Endothelial Growth Factor Production in Colorectal Cancer
Purpose: Activity of histidine decarboxylase, the key enzyme in the synthesis of histamine, has been shown to be increased in several types of human tumors. We attempted to establish whether the
Expression of matrix metalloproteinase 1, matrix metalloproteinase 2, and matrix metalloproteinase 9 in carcinoma of the head and neck
Whether the expression of MMPs in HNSCC is correlated with other steps involved in tumor growth and metastasis, like angiogenesis, activation the nitric oxide (NO) pathway, and alteration of the p53 tumor suppressor gene is examined.
Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer.
The NO pathway appears to play a key role in tumor angiogenesis and spread in patients with head and neck cancer.
Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma.
A close correlation between COX-2 pathway, VEGF expression, and tumor angiogenesis in HNSCC is demonstrated and appears to predict a shorter survival in patients with head and neck cancer.
Relaxin protects against myocardial injury caused by ischemia and reperfusion in rat heart.
This study shows that relaxin can be regarded as an agent with a marked cardioprotective action against ischemia-reperfusion-induced myocardial injury.
Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer. Implications for tumor angiogenesis and metastasis.
A central role of COX-2 pathway is suggested in HNC angiogenesis by modulating VEGF production and indicates that COx-2 inhibitors may be useful in H NC treatment.