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Deoxycholic Acid Induces Intracellular Signaling through Membrane Perturbations*
Data suggest that bile acid-induced signaling is initiated through alterations of the plasma membrane structure and the redistribution of cholesterol. Expand
Monomethylarsonous acid induces transformation of human bladder cells.
These observations are the first demonstration of MMA( III)-induced malignant transformation in a human bladder urothelial cell line and provide important evidence that MMA(III) may be carcinogenic in human tissues. Expand
Monomethylarsonous acid (MMA(III)) and arsenite: LD(50) in hamsters and in vitro inhibition of pyruvate dehydrogenase.
It is demonstrated that MMA(III) is more toxic than inorganic arsenite, both in vivo and in vitro, and the hypothesis that methylation of inorganic arsenic is a detoxication process is called into question. Expand
Substrate-Dependent Ligand Inhibition of the Human Organic Cation Transporter OCT2
Data show that the choice of OCT2 substrate significantly influences both quantitative and qualitative inhibitory interactions with cationic drugs; and ligand interactions with OCT2 are not restricted to competition for a common ligand binding site, consistent with a binding surface characterized by multiple, possibly overlapping interaction sites. Expand
A cytochrome P450 terpenoid hydroxylase linked to the suppression of insect juvenile hormone synthesis.
Omega-hydroxylation of sesquiterpenoids appears to be a metabolic pathway in the corpora allata that may play a role in the suppression of JH biosynthesis at the end of the gonotrophic cycle. Expand
Arsenite and monomethylarsonous acid generate oxidative stress response in human bladder cell culture.
UROtsa cells, an immortalized human urothelial cell line, were used to study the effects of arsenicals on the human bladder, a site of arsenical bioconcentration and carcinogenesis, providing evidence for a different mechanism of MMA( III) toxicity, one that MMA(III) first interacts with cellular components before an ROS response is generated, taking longer to produce the effect, but with more substantial harm to the cell. Expand
2,2',3,3',6,6'-hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P450 2B1 and 2B11.
The findings from this study demonstrate the importance of residues 114, 206, 209, 302, 363, 367, 477, 478, and 480 in 2B1 and 114, 290, and 363 in 2 B11 for 236HCB metabolism. Expand
Molecular Pharmacology and Antitumor Activity of PHT-427, a Novel Akt/Phosphatidylinositide-Dependent Protein Kinase 1 Pleckstrin Homology Domain Inhibitor
The molecular pharmacology and antitumor activity of PHT-427, a compound designed to bind to the pleckstrin homology (PH) binding domain of signaling molecules important in cancer, is reported, with significant in vivo antitumors activity and minimal toxicity. Expand
Bright blue organic light-emitting diode with improved color purity using a LiF/Al cathode
We report a two-layer, blue organic light-emitting diode with a 4,4′-bis(2,2-diphenylvinyl)-1,1′-biphenyl emission layer and a LiF/Al cathode which has an external quantum efficiency of 1.4% and aExpand
NBD-TMA: a novel fluorescent substrate of the peritubular organic cation transporter of renal proximal tubules
The experimental results provide strong evidence that NBD-TMA+ is transported by one or more of the basolateral organic cation transporters involved in the renal secretion of this chemical class of compound. Expand