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Risk and prevention of graft failure in patients with preexisting donor-specific HLA antibodies undergoing unmanipulated haploidentical SCT
A role of donor-specific HLA antibodies (DSA) in graft failure after SCT has been suggested, but the relevance of DSA in unmanipulated haploidentical SCT (haplo-SCT) remains unknown. We prospectively… Expand
Feasibility of HLA-haploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)-mismatched family members linked with long-term fetomaternal microchimerism.
Based on the hypothesis that long-term fetomaternal microchimerism is associated with acquired immunologic hyporesponsiveness to noninherited maternal antigens (NIMAs) or inherited paternal antigens… Expand
Association of a new allele of the TAP2 gene, TAP2*Bky2 (Val577), with susceptibility to Sjögren's syndrome.
- S. Kumagai, S. Kanagawa, +5 authors H. Saji
- Medicine, Biology
- Arthritis and rheumatism
- 1 September 1997
OBJECTIVE To investigate the polymorphisms of TAP (transporters associated with antigen processing) genes among patients with primary Sjögren's syndrome (SS) in order to clarify the potential… Expand
Epitopes of human leukocyte antigen class I antibodies found in sera of normal healthy males and cord blood.
This study defines 96 epitopes targeted by human leukocyte antigen (HLA) antibodies reported in the sera of normal healthy males with no history of deliberate alloimmunizations and in cord blood.… Expand
Evidence that CD31, CD49b, and CD62L are immunodominant minor histocompatibility antigens in HLA identical sibling bone marrow transplants.
Despite complete matching of siblings for the HLA loci, after bone marrow transplantation (BMT), approximately 20% develop graft-versus-host disease (GVHD). This is presumably due to incompatibility… Expand
Genetic Contribution of Tumor Necrosis Factor (TNF)‐α Gene Promoter (−1031, −863 and −857) and TNF Receptor 2 Gene Polymorphisms in Endometriosis Susceptibility
- M. Teramoto, J. Kitawaki, +10 authors H. Honjo
- Medicine, Biology
- American journal of reproductive immunology
- 1 May 2004
Problem: Tumor necrosis factor (TNF)‐α is a major cytokine involved in inflammatory and immune function. The aim of this study was to investigate whether polymorphisms at positions −1031, −863 and… Expand
PCR-LIS-SSCP (Low ionic strength single-stranded conformation polymorphism)--a simple method for high-resolution allele typing of HLA-DRB1, -DQB1, and -DPB1.
We have developed a simple and efficient procedure with which to form single-stranded DNA [ssDNA] and then applied HLA-DRB1, -DQB1, and -DPB1 allele typing. This method is referred to as low ionic… Expand
Phenotype Frequencies of Autosomal Minor Histocompatibility Antigens Display Significant Differences among Populations
Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen–matched solid organ and stem cell transplantation… Expand
Fetal-maternal microchimerism: impact on hematopoietic stem cell transplantation.
- T. Ichinohe, T. Teshima, K. Matsuoka, E. Maruya, Hiroh Saji
- Medicine, Biology
- Current opinion in immunology
- 1 October 2005
Reciprocal cell traffic between mother and fetus during pregnancy gives rise to postpartum fetal-maternal lymphohematopoietic microchimerism, which is frequently detected in blood or tissue from… Expand
Association between type 1 diabetes age-at-onset and intercellular adhesion molecule-1 (ICAM-1) gene polymorphism.
We investigated the intercellular adhesion molecule-1 (ICAM-1) gene polymorphism in 90 patients with young-onset type 1 diabetes, 74 with adult-onset type 1 diabetes, and 171 control subjects. The… Expand