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Human ATAC Is a GCN5/PCAF-containing Acetylase Complex with a Novel NC2-like Histone Fold Module That Interacts with the TATA-binding Protein*
Eukaryotic GCN5 acetyltransferases influence diverse biological processes by acetylating histones and non-histone proteins and regulating chromatin and gene-specific transcription as part ofExpand
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Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters.
The core promoter of eukaryotic genes is the minimal DNA region that recruits the basal transcription machinery to direct efficient and accurate transcription initiation. The fraction of human andExpand
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Multi-protein complexes in eukaryotic gene transcription
  • E. Martinez
  • Biology, Medicine
  • Plant Molecular Biology
  • 1 December 2002
Specific transcription initiation by RNA polymerase II at eukaryotic protein-coding genes involves the cooperative assembly at the core promoter of more than 40 distinct proteins – with a total massExpand
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c-Myc Transformation Domain Recruits the Human STAGA Complex and Requires TRRAP and GCN5 Acetylase Activity for Transcription Activation*
Deregulation of the c-Myc oncoprotein (Myc) is implicated in many types of cancer. Myc is a sequence-specific transcription factor that regulates transcription of genes involved in the control ofExpand
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Dual Regulation of c-Myc by p300 via Acetylation-Dependent Control of Myc Protein Turnover and Coactivation of Myc-Induced Transcription
ABSTRACT The c-Myc oncoprotein (Myc) controls cell fate by regulating gene transcription in association with a DNA-binding partner, Max. While Max lacks a transcription regulatory domain, the NExpand
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Cooperative binding of estrogen receptor to imperfect estrogen‐responsive DNA elements correlates with their synergistic hormone‐dependent enhancer activity.
The Xenopus vitellogenin (vit) gene B1 estrogen‐inducible enhancer is formed by two closely adjacent 13 bp imperfect palindromic estrogen‐responsive elements (EREs), i.e. ERE‐2 and ERE‐1, having oneExpand
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BS69/ZMYND11 C-Terminal Domains Bind and Inhibit EBNA2
Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) plays an important role in driving immortalization of EBV-infected B cells through regulating the expression of many viral and cellular genes. WeExpand
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Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression
  • W. Wahli, E. Martinez
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 1 June 1991
The nuclear hormone receptor superfamily is characterized by an impressive functional diversity of its members despite a remarkable overall structural unity. A variety of ligands bind specifically toExpand
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Reconstitution of an E box-binding Myc:Max complex with recombinant full-length proteins expressed in Escherichia coli.
The c-Myc oncoprotein (Myc) is a DNA sequence-specific transcription factor that regulates transcription of a wide variety of genes involved in the control of cell growth, proliferation,Expand
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The estrogen‐responsive element as an inducible enhancer: DNA sequence requirements and conversion to a glucocorticoid‐responsive element.
The estrogen‐responsive element (ERE) present in the 5′‐flanking region of the Xenopus laevis vitellogenin (vit) gene B1 has been characterized by transient expression analysis of chimeric vit‐tk‐CATExpand
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