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Efficacy of high-dose versus standard-dose influenza vaccine in older adults.
Among persons 65 years of age or older, IIV3-HD induced significantly higher antibody responses and provided better protection against laboratory-confirmed influenza illness than did IIV3-SD. Expand
Inhibition of Human Cholinesterases by Drugs Used to Treat Alzheimer Disease
Development of drugs targeted toward the exclusive inhibition of one or the other cholinesterase may be important for understanding the relative importance of inhibition of BuChE and AChE in the treatment of this disease. Expand
Butyrylcholinesterase Is Associated With &bgr;-Amyloid Plaques in the Transgenic APPSWE/PSEN1dE9 Mouse Model of Alzheimer Disease
Histochemical analysis of Alzheimer disease brain tissues indicates that butyrylcholinesterase (BuChE) is present in A&bgr;-amyloid plaques and may play a role in AD plaque maturation, and observations suggest that BuChE is associated with a subpopulation of A& bgr; plaques. Expand
On the active site for hydrolysis of aryl amides and choline esters by human cholinesterases.
Based on the substrate structure-activity relationships and kinetic studies, the hydrolysis of anilides and esters of choline appears to utilize the same catalytic site in BuE, and N-(2-nitrophenyl)alkylamides with six to eight carbon atoms in the acyl group represent suitable specific substrates to investigate further the function of the AAA activity of BuChE. Expand
Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase.
The involvement of the E-helix in phenothiazine carbamate reversible inhibition of butyrylcholinesterase is confirmed and represents a domain that could be exploited for development of specific inhibitors to treat dementias. Expand
Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine.
Evidence suggests that specific inhibition of butyrylcholinesterase may be an appropriate focus for the development of more effective drugs to treat dementias such as Alzheimer's disease.Expand
Differential effects of lipid-lowering agents on human cholinesterases.
Some "statins" inhibit butyrylcholinesterase, which suggests a possible means whereby "Statins" could protect against dementia. Expand
Butyrylcholinesterase-Mediated Enhancement of the Enzymatic Activity of Trypsin
It is suggested that, in addition to its esterase activity, BuChE may assume a regulatory role by interacting with other proteins as well as copurify with peptidases. Expand
Enantiomer Effects of Huperzine A on the Aryl Acylamidase Activity of Human Cholinesterases
The two huperzine enantiomers may prove to be useful tools to examine the function of aryl acylamidase activity, including its role in Alzheimer pathology. Expand
Cysteine thioesters as myelin proteolipid protein analogues to examine the role of butyrylcholinesterase in myelin decompaction.
A series of increasing chain length acyl thioester derivatives of N-acetyl-l-cysteine methyl ester were synthesized and examined for hydrolysis by human cholinesterases, finding the affinity of BuChE for the compound increased the longer the fatty acid chain, with the highest affinity for cysteine bound to palmitic acid. Expand