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Physiologically based biokinetic (PBBK) modeling of safrole bioactivation and detoxification in humans as compared with rats.
A physiologically based biokinetic (PBBK) model for the alkenylbenzene safrole in humans was developed based on in vitro- and in silico-derived kinetic parameters. With the model obtained, the time-Expand
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Malabaricone C-containing mace extract inhibits safrole bioactivation and DNA adduct formation both in vitro and in vivo.
Safrole, present in mace and its essential oils, causes liver tumors in rodents at high dose levels due to formation of a DNA reactive 1'-sulfooxysafrole. The present study identifies malabaricone CExpand
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A physiologically based kinetic (PBK) model for safrole bioactivation and detoxification in rat and
The objective of the present study was to build a physiologically ased kinetic (PBK) model providing insight in dose-dependent hanges in safrole metabolism with emphasis on detoxification andExpand
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Detoxification of Yam Tuber (Dioscorea hispida Dennst.) by Limited Heating in Yam Flour Processing
Yams is one of the tuber crops in Indonesia. Meanwhile, people still unaware to consumed it and its derivative product because of the toxic compound such as alkaloid (dioscorin) and also cyanide. ForExpand
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KARAKTERISTIK FISIKOKIMIA DAN SENSORIS FRUIT LEATHER APEL MANALAGI (Malus sylvestris mill) DENGAN SUBTITUSI PISANG CANDI (Musa paradisiaca)
Fruit Leather merupakan salah satu olahan yang berbahan dasar buah-buahan yang dihaluskan (bubur buah) dengan cara mengurangi kadar air dari produk tersebut. Tujuan dari penelitian ini adalahExpand
Efectiveness of Whey Protein Consentrates and Dextrins to Maintain Viability of Lactic Acid Bacteria in Frozen Dried Starter Yoghurt
The aim of this research was to investigate the effect of dextrins (0, 35, 40 and 45% (w/w) as cryoprotectant agent and whey protein concentrates (WPC) (0, 2 and 4% (w/v)) as nutrition which promoteExpand
Profil Gliserida, dan Kandungan EPA (Eicosapentaenoat) dan DHA (Docosaheksaenoat) Hasil Hidrolisis Minyak Hati Ikan Cod oleh Lipase Teramobil dari Mucor Miehei
Hydrolysis of cod liver oil by immobilized lipase from Mucor miehei was studied to observe the hydrolysis level, glycerides profile and EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid)Expand
Physiologically based biokinetic (PBBK) modeling and validation of dose-, species-, interindividual- and matrix dependent effects on the bioactivation and detoxification of safrole
Keywords: safrole, PBBK model, DNA adduct, mace Safrole has been demonstrated to be carcinogenic in rodent studies at high doses of the pure compound. The use of pure safrole in foodshas already beenExpand
Traditional drink of black cincau (Mesona palustris BL)-based wedang uwuh as immunomodulator on alloxan-induced diabetic rats
This study aims to evaluate the immunomodulatory effect of traditional drink of black cincau-based wedang uwuh (WUB) on alloxan-induced diabetic rats.,WUB consists of dried herbs such as black cincauExpand
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