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DIP: the Database of Interacting Proteins
The Database of Interacting Proteins (DIP; http://dip.doe-mbi.ucla.edu) is a database that documents experimentally determined protein-protein interactions. This database is intended to provide theExpand
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The genome sequence of the filamentous fungus Neurospora crassa
Neurospora crassa is a central organism in the history of twentieth-century genetics, biochemistry and molecular biology. Here, we report a high-quality draft sequence of the N. crassa genome. TheExpand
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Assigning protein functions by comparative genome analysis: protein phylogenetic profiles.
Determining protein functions from genomic sequences is a central goal of bioinformatics. We present a method based on the assumption that proteins that function together in a pathway or structuralExpand
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Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation
We report a method for large-scale absolute protein expression measurements (APEX) and apply it to estimate the relative contributions of transcriptional- and translational-level gene regulation inExpand
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Insights into the regulation of protein abundance from proteomic and transcriptomic analyses
Recent advances in next-generation DNA sequencing and proteomics provide an unprecedented ability to survey mRNA and protein abundances. Such proteome-wide surveys are illuminating the extent toExpand
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Comparative experiments on learning information extractors for proteins and their interactions
OBJECTIVE Automatically extracting information from biomedical text holds the promise of easily consolidating large amounts of biological knowledge in computer-accessible form. This strategy isExpand
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Prioritizing candidate disease genes by network-based boosting of genome-wide association data.
Network "guilt by association" (GBA) is a proven approach for identifying novel disease genes based on the observation that similar mutational phenotypes arise from functionally related genes. InExpand
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A Census of Human Soluble Protein Complexes
Cellular processes often depend on stable physical associations between proteins. Despite recent progress, knowledge of the composition of human protein complexes remains limited. To close this gap,Expand
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Characterising and Predicting Haploinsufficiency in the Human Genome
Haploinsufficiency, wherein a single functional copy of a gene is insufficient to maintain normal function, is a major cause of dominant disease. Human disease studies have identified several hundredExpand
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A Probabilistic Functional Network of Yeast Genes
A conceptual framework for integrating diverse functional genomics data was developed by reinterpreting experiments to provide numerical likelihoods that genes are functionally linked. This allowsExpand
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