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Oxyhaemoglobin increases the production of endothelin-1 by endothelial cells in culture.
Cultured endothelial cells from bovine thoracic aortas conditioned with serum-free culture media released an endothelin-1 (ET)-1-like substance. Concentrations of ET-1-like material were determinedExpand
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Analysis of dose-response curves and calculation of agonist dissociation constants using a weighted nonlinear curve fitting program.
The KA value of a full agonist (Furchgott, 1966) is usually calculated following the transformation of a rectangular hyperbolic relationship between equiactive concentrations into a linearExpand
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The in vitro pharmacology of xamoterol (ICI 118,587)
1 The effect of xamoterol and (‐)‐isoprenaline have been compared for their activity at β‐adrenoceptor sites in a number of in vitro cardiac and smooth muscle preparations. 2 Xamoterol produced weakExpand
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Autoradiographic localization and function of β‐adrenoceptors on the human internal mammary artery and saphenous vein
1 Receptor autoradiography with (−)‐[125 I]‐cyanopindolol (CYP) was used to study the distribution of β1 and β2‐adrenoceptor subtypes in the human internal mammary artery and saphenous vein. 2 ImagesExpand
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Comparison of guinea pig uterine and rat vas deferens preparations for assessment of beta 2-adrenoceptor-mediated activity.
In the present study, investigations were performed to determine the subtype(s) of beta-receptor-mediating relaxation in K+-depolarized guinea pig uterine preparations, and inhibition of twitches inExpand
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EFFECTS OF PHENOXYBENZAMINE ON RESPONSES TO SOME RECEPTOR AGONISTS AND CALCIUM IN VITRO
1. Noradrenaline‐induced contractions of the rabbit and rat isolated aorta and guinea‐pig spleen strips were inhibited by concentrations of phenoxybenzamine which did not affect responses to calcium.Expand
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Beta-adrenoceptor selectivity of dobutamine: in vivo and in vitro studies.
We compared the beta-adrenoceptor stimulant actions of dobutamine and (-)-isoprenaline in isolated tissue preparations (atria, trachea, and uterus) from the guinea pig and inExpand
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β-Adrenoceptors involved in inhibition of histamine release from sensitized guinea-pig lung
Abstract Selective β-adrenoceptor agonists and antagonists were used to study the type of β-adrenoceptors involved in inhibiting antigen-induced histamine release from actively sensitized guinea-pigExpand
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In vitro ACTIVITY OF RO363, A β1‐ADRENOCEPTOR SELECTIVE AGONIST
1 The β‐adrenoceptor stimulant effects of RO363 and (−)‐isoprenaline have been compared in a variety of isolated tissue preparations. 2 RO363 is approximately half as potent as (−)‐isoprenaline inExpand
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Role of efficacy in the assessment of the actions of α‐adrenoceptor agonists in rat aorta with endothelium
Concentration‐effect curves to phenylephrine are shifted to the right in the presence of endothelium in rat aorta while responses to clonidine are practically abolished. Analysis of theExpand
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