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Hypoxia-induced gene expression in chemoradioresistant cervical cancer revealed by dynamic contrast-enhanced MRI.
The findings reveal the molecular basis of an aggressive hypoxic phenotype and suggest the use of DCE-MRI to noninvasively identify patients with hypoxia-related chemoradioresistance.
Dosimetric impact of interobserver variability in MRI-based delineation for cervical cancer brachytherapy.
Classification of Dynamic Contrast Enhanced MR Images of Cervical Cancers Using Texture Analysis and Support Vector Machines
The results indicate that the spatial relations within the tumor, quantified by texture features, were more suitable for outcome prediction than first-order features.
Optimization of tumour control probability in hypoxic tumours by radiation dose redistribution: a modelling study.
- Å. Søvik, E. Malinen, Ø. Bruland, S. Bentzen, D. Olsen
- MedicinePhysics in medicine and biology
- 21 January 2007
Red redistributing dose according to tumour oxygenation status might increase TCP when the tumour response to radiotherapy is limited by chronic hypoxia, which could potentially improve treatment outcome in a subpopulation of patients who respond poorly to conventional radiotherapy.
Pharmacokinetic parameters derived from dynamic contrast enhanced MRI of cervical cancers predict chemoradiotherapy outcome.
The energy dependence of lithium formate and alanine EPR dosimeters for medium energy x rays.
This work shows that lithium formate dosimeters are less dependent on x-ray energy than alanine, and the yield of radiation-induced radicals is decreased following x-irradiation compared to irradiation with 60Co y-rays.
Alanine Radicals, Part 4: Relative Amounts of Radical Species in Alanine Dosimeters after Exposure to 6–19 MeV Electrons and 10 kV–15 MV Photons
The relative contributions of the different radical species to the total EPR signal from alanine dosimeters irradiated with 6–19 MeV electrons and 10 kV–15 MV photons at a dose of 10 Gy were examined and showed to be virtually independent of these radiation beam qualities.
EPR dosimetric properties of formates.
Radiotherapy adapted to spatial and temporal variability in tumor hypoxia.
Alanine Radicals, Part 3: Properties of the Components Contributing to the EPR Spectrum of X-Irradiated Alanine Dosimeters
It is concluded that even if it is now realized that three different radicals contribute to the composite EPR alanine spectrum, this has a minor impact on the established protocols for present-day applications (high-dose) of EPR/alanine dosimetry.