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Antibiotic‐induced expression of a cryptic cpb2 gene in equine β2‐toxigenic Clostridium perfringens
The cpb2 gene of β2‐toxigenic Clostridium perfringens isolated from horses, cattle, sheep, human and pigs was sequenced, and the first report on expression of a bacterial toxin gene by antibiotic‐induced ribosomal frameshifting is reported. Expand
Mycoplasma leachii sp. nov. as a new species designation for Mycoplasma sp. bovine group 7 of Leach, and reclassification of Mycoplasma mycoides subsp. mycoides LC as a serovar of Mycoplasma mycoides
The Mycoplasma mycoides cluster consists of six pathogenic mycoplasmas causing disease in ruminants, which share many genotypic and phenotypic traits and the present paper proposes an emended taxonomy of this cluster, which will hereafter be composed of five taxa comprising three subclusters. Expand
Discovery of insertion element ISCfe1: a new tool for Campylobacter fetus subspecies differentiation.
The identification of a new insertion element, ISC Fe1, which is present exclusively in CFV strains, with highly conserved specific ISCfe1 insertion sites are described, which are useful for identification and differentiation of the two C. fetus subspecies and will help in understanding the evolution and pathogenesis of C.etus. Expand
A Metabolic Enzyme as a Primary Virulence Factor of Mycoplasma mycoides subsp. mycoides Small Colony
ABSTRACT During evolution, pathogenic bacteria have developed complex interactions with their hosts. This has frequently involved the acquisition of virulence factors on pathogenicity islands,Expand
Molecular mechanisms of pathogenicity of Mycoplasma mycoides subsp. mycoides SC
This strategy enables the mycoplasma to exploit the minimal genetic information in its small genome, not only to fulfil the basic functions for its replication but also to damage host cells in intimate proximity thereby acquiring the necessary bio-molecules, such as amino acids and nucleic acid precursors, for its own biosynthesis and survival. Expand
The Origin of the ‘Mycoplasma mycoides Cluster’ Coincides with Domestication of Ruminants
The origin of the ‘M. mycoides cluster’ dates to about 10,000 years ago, suggesting that the establishment and spread of the cluster coincided with livestock domestication, and it is shown that hybridization and recombination may be important factors in the evolutionary history of this cluster. Expand
Characterization of LppS, an adhesin of Mycoplasma conjunctivae.
A serine-rich membrane protein named LppS from Mycoplasma conjunctivae, the aetiological agent of infectious keratoconjunctivitis (IKC) of domestic and wild Caprinae, was characterized and is likely to be an adhesin of M. conjunctIVae that may play an important role in the pathogenesis of IKC. Expand
Characterization and Analysis of a Stable Serotype-Associated Membrane Protein (P30) of Mycoplasma agalactiae
Analysis of sera from sheep that were experimentally infected with M. agalactiae revealed that P30 induced a strong and persistent immune response which was still very high two months after infection, in contrast, currently used enzyme-linked immunosorbent assay serology gave only low titers. Expand
IS1634, a Novel Insertion Element Creating Long, Variable-Length Direct Repeats Which Is Specific for Mycoplasma mycoides subsp. mycoides Small-Colony Type
A new insertion sequence, IS1634, has been identified in Mycoplasma mycoides small-colony type (SC), which shows structural and functional similarities to IS1549 of Mycobacterium smegmatis and seems to form a new class or family of insertion sequences. Expand
Comparative analysis of four lipoproteins from Mycoplasma mycoides subsp. mycoides Small Colony identifies LppA as a major T-cell antigen.
LppA is an important target for the CD4 T-cells generated early after MmmSC infection and persisting in the lymph nodes of recovered cattle, and its role as a protective antigen and ability to in vivo trigger both arms of the host immune response remain to be evaluated. Expand