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Tumor spectrum analysis in p53-mutant mice
BACKGROUND The p53 tumor suppressor gene is mutated in a large percentage of human malignancies, including tumors of the colon, breast, lung and brain. Individuals who inherit one mutant allele ofExpand
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Effects of an Rb mutation in the mouse
The retinoblastoma gene is mutated in several types of human cancer and is the best characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one allele of Rb isExpand
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p53 is required for radiation-induced apoptosis in mouse thymocytes
THE p53 tumour suppressor gene is the most widely mutated gene in human tumorigenesis1,2. p53 encodes a transcriptional activator3–7 whose targets may include genes that regulate genomicExpand
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Tumour predisposition in mice heterozygous for a targeted mutation in Nf1
Human neurofibromatosis type 1 is a dominant disease caused by the inheritance of a mutant allele of the NF1 gene. In order to study NF1 function, we have constructed a mouse strain carrying aExpand
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Extensive contribution of Rb‐deficient cells to adult chimeric mice with limited histopathological consequences.
Homozygosity for a mutation in the Rb tumor suppressor gene causes mid‐gestation embryonic lethality in the mouse. Using a two‐step targeting protocol, we have constructed Rb homozygous mutant mouseExpand
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Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways.
An important component of cytokine regulation of cell growth and differentiation is rapid transcriptional activation of genes by the JAK-STAT (signal transducer and activator of transcription)Expand
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Inhibition of transcription factor Stat1 activity in mononuclear cell cultures and T cells by the cyclic AMP signaling pathway.
Activation of T cells results in a cascade of gene activation and subsequent proliferation and differentiation into effector phenotypes. The regulation of transcription factors belonging to theExpand
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