E. M. Huber

Publications189
h-index16
Citations1,240
Highly Influential Citations55
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Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity
A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome
TLDR
Insight is provided into the basic mechanism of proteolysis and propeptide autolysis, as well as the evolutionary pressures that drove the proteasome to become a threonine protease.
The Mammalian Proteasome Activator PA28 Forms an Asymmetric α4β3 Complex.
Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
DNA minor groove sensing and widening by the CCAAT-binding complex.
Inhibitors for the Immuno‐ and Constitutive Proteasome: Current and Future Trends in Drug Development
Inhibitors for the immuno- and constitutive proteasome: current and future trends in drug development.
TLDR
The recently determined crystal structure of the iCP will further promote the development and optimization of iCP-selective compounds, and appears to be a promising therapeutic rationale for the treatment of autoimmune disorders.
Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes.
TLDR
The development of cell-permeable β1i and β5i selective inhibitors that outperform existing leads in terms of selectivity and/or potency are reported.
Flavoenzyme-catalyzed formation of disulfide bonds in natural products.
TLDR
Despite their differently sized substrate binding clefts and hence, their diverse substrate preferences, a unifying reaction mechanism is proposed based on the obtained crystal structures and further supported by mutagenesis experiments.
Dissection of glutathione conjugate turnover in yeast.
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