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Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes
Canonical Wnt signaling requires inhibition of Glycogen Synthase Kinase 3 (GSK3) activity, but the molecular mechanism by which this is achieved remains unclear. Here, we report that Wnt signalingExpand
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Integrating Patterning Signals: Wnt/GSK3 Regulates the Duration of the BMP/Smad1 Signal
BMP receptors determine the intensity of BMP signals via Smad1 C-terminal phosphorylations. Here we show that a finely controlled cell biological pathway terminates this activity. The duration of theExpand
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Evo-Devo: Variations on Ancestral Themes
Most animals evolved from a common ancestor, Urbilateria, which already had in place the developmental genetic networks for shaping body plans. Comparative genomics has revealed rather unexpectedlyExpand
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Spemann's organizer and self-regulation in amphibian embryos
In 1924, Spemann and Mangold demonstrated the induction of Siamese twins in transplantation experiments with salamander eggs. Recent work in amphibian embryos has followed their lead and uncoveredExpand
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Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles
Signal transduction and endocytosis are intertwined processes. The internalization of ligand-activated receptors by endocytosis has classically been thought to attenuate signals by targetingExpand
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The ancestry of segmentation
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Extracellular regulation of BMP signaling
In the developing organism, cells differentiate, divide and die as part of groups of hundreds or thousands of cells called 'morphogenetic fields'. Fields have the remarkable property ofExpand
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The Tumor Suppressor Smad 4 / DPC 4 Is Regulated by Phosphorylations that Integrate FGF , Wnt , and TGF-b Signaling Graphical
Graphical Abstract Highlights The tumor suppressor Smad4 is regulated by FGF/MAPK and Wnt/GSK3 phosphorylations Sequential phosphorylations control both Smad4 activity and degradation by b-TrCP InExpand
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Wnt Signaling in Axial Patterning and Regeneration: Lessons from Planaria
Wnt signal transduction plays a crucial role in stem cell proliferation and regeneration. When canonical Wnt signaling is low, heads develop, and when it is high, tails are formed. In planarians, WntExpand
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