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Neuroendocrine control of growth hormone secretion.
The secretion of growth hormone (GH) is regulated through a complex neuroendocrine control system, especially by the functional interplay of two hypothalamic hypophysiotropic hormones, GH-releasing
Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients.
Evidence of an age-related decline of plasma ghrelin concentrations is provided, which might explain, at least partially, the somatotroph dysregulation and the anorexia of the elderly subject.
Children with Prader-Willi syndrome exhibit more evident meal-induced responses in plasma ghrelin and peptide YY levels than obese and lean children.
The finding of a meal-induced decrease and increase in ghrelin and PYY levels respectively in PWS children would imply that the regulation of appetite/satiety of these peptides is operative during childhood, and it progressively deteriorates and vanishes in adulthood when hyperphagia and obesity worsen.
Altered growth hormone and prolactin responses to dopaminergic stimulation in Huntington's chorea.
The results suggest the existence of an abnormal regulation of GH and PRL secretion in Huntington's chorea, probably due to alterations in central dopaminergic neurotransmission.
Neural control of somatotropic function.
  • E. Müller
  • Medicine
    Physiological reviews
  • 1 July 1987
One month of streptozotocin-diabetes induces different neuroendocrine and morphological alterations in the hypothalamo-pituitary axis of male and female rats.
The studies indicate that the hypothalamo-pituitary changes that occur early in streptozotocin-treated rats are unrelated to undernourishment and are possibly caused by insulin deficiency, and some anatomical data indicates that the brain and pituitary are less severely affected by diabetes in female than in male animals.
Leptin regulates GH secretion in the rat by acting on GHRH and somatostatinergic functions.
It is demonstrated that leptin is a metabolic signal that regulates GH secretion in the rat by acting on hypothalamic GH-regulatory hormones.