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Comparison of the Transcription and Replication Strategies of Marburg Virus and Ebola Virus by Using Artificial Replication Systems
To compare the replication and transcription strategies of both viruses, an artificial replication system based on the vaccinia virus T7 expression system was established for EBOV and it was observed that neither MBGV nor E BOV were able to replicate the heterologous minigenomes.
Processing of Genome 5′ Termini as a Strategy of Negative-Strand RNA Viruses to Avoid RIG-I-Dependent Interferon Induction
RIG-I is established as a major intracellular recognition receptor for the genome of most negative-strand RNA viruses and the cleavage of triphosphates at the RNA 5′ end as a strategy of viruses to evade the innate immune response is defined.
The Ebola Virus VP35 Protein Inhibits Activation of Interferon Regulatory Factor 3
The data suggest that in Ebola virus-infected cells, VP35 inhibits the induction of antiviral genes, including the IFN-β gene, by blocking IRF-3 activation.
Taxonomy of the order Mononegavirales: update 2016
The updated taxonomy of the order Mononegavirales is presented as now accepted by the International Committee on Taxonomy of Viruses (ICTV).
The Ebola virus VP35 protein functions as a type I IFN antagonist.
The Ebola virus VP35 protein is likely to inhibit induction of type I IFN in Ebola virus-infected cells and may be an important determinant of Ebola virus virulence in vivo.
Marburg Virus Evades Interferon Responses by a Mechanism Distinct from Ebola Virus
This study shows that MARV inhibits IFN signaling by a mechanism different from that employed by the related EBOV and identifies a novel function for the MARV VP40 protein and suggests thatMARV may globally inhibit Jak1-dependent cytokine signaling.
Interactions of Marburg virus nucleocapsid proteins.
- S. Becker, C. Rinné, U. Hofsaess, H. Klenk, E. Mühlberger
- Biology, ChemistryVirology
- 30 September 1998
The components of Marburg virus nucleocapsid complex were determined, and interactions between the compounds were investigated, and immunofluorescence analysis of coexpressed proteins was carried out.
Filovirus replication and transcription.
- E. Mühlberger
- BiologyFuture virology
- 21 February 2007
The current knowledge of the replication and transcription strategy of Marburg and Ebola virus is reviewed, with focus on the observed differences.
Three of the Four Nucleocapsid Proteins of Marburg Virus, NP, VP35, and L, Are Sufficient To Mediate Replication and Transcription of Marburg Virus-Specific Monocistronic Minigenomes
Northern blot analysis of viral RNA revealed that three nucleocapsid proteins were essential and sufficient for transcription as well as replication and encapsidation and indicate that VP35, rather than VP30, is the functional homologue of rhabdo- and paramyxovirus P proteins.
Ebola Virus VP35 Antagonizes PKR Activity through Its C-Terminal Interferon Inhibitory Domain
It is shown that the IRF inhibitory domain of VP35 mediates the inhibition of PKR and enhances the synthesis of coexpressed proteins in Ebola virus infection.