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HK3 overexpression associated with epithelial-mesenchymal transition in colorectal cancer
TLDR
Upregulation of HK3 is associated with EMT in CRC and may be a crucial metabolic adaptation for rapid proliferation, survival, and metastases of CRC cells.
Immunohistochemistry and Mutation Analysis of SDHx Genes in Carotid Paragangliomas
TLDR
Results indicate that SDH immunohistochemistry does not fully reflect the presence of mutations in the genes; diagnostic effectiveness of this method was 71%.
Exome analysis of carotid body tumor
TLDR
Exome analysis of 52 CBTs for the first time revealed the average mutation load for these tumors and also identified potential driver mutations as well as their frequencies and co-occurrence with the other PDMs.
Transcriptome analysis reveals mechanisms of geroprotective effects of fucoxanthin in Drosophila
TLDR
Life-extending effects of fucoxanthin are associated with differential expression of longevity-associated genes, including MAPK, mTOR, Wnt, Notch, and Hippo signaling pathways.
Effect of Rotary Swaging on Microstructure, Texture, and Mechanical Properties of a Mg‐Al‐Zn Alloy
The effect of rotary swaging on the microstructure, texture, and mechanical properties of the magnesium alloy Mg‐4.4Al‐0.9Zn‐0.4Mn is studied. Repetitive processing, conducted at progressively
Mutational load in carotid body tumor
TLDR
The developed approach, developed and successfully applied a complex approach for the analysis of sequencing data estimated the mutational load in CBT, which is much lower than in common malignant tumors.
Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer
TLDR
A bioinformatic analysis of a The Cancer Genome Atlas data and RNA-Seq profiling of a Russian patient cohort is performed to reveal prognostic markers of locally advanced lymph node-negative prostate cancer (lymph nodes-negative LAPC), and genes for the TMPRSS2-ERG prostate cancer molecular subtype are revealed.
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