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3-(2,2,2-Trimethylhydrazinium)propionate (THP)--a novel gamma-butyrobetaine hydroxylase inhibitor with cardioprotective properties.
- B. Simkhovich, Z. Shutenko, +5 authors E. Lukevics,
- Chemistry, Medicine
- Biochemical pharmacology
- 15 January 1988
A protein fraction containing gamma-butyrobetaine hydroxylase (sp.act. 1.54 mU/mg) was isolated from the rat liver by differential precipitation with ammonium sulphate.… Expand
Synthesis and antitumour activity of trimethylsilylpropyl substituted benzimidazoles.
- E. Lukevics,, P. Arsenyan, I. Shestakova, I. Domracheva, A. Nesterova, O. Pudova
- Chemistry, Medicine
- European journal of medicinal chemistry
- 1 June 2001
The quaternisation of N-substituted benzimidazoles by heating with various alkyl, allyl, propargyl and benzyl chlorides and bromides leads to the formation of benzimidazolinium salts. The interaction… Expand
Indole and Isatin Oximes: Synthesis, Reactions, and Biological Activity. (Review)
Data on methods for the production of isatin and indole aldoximes, ketoximes, and amidoximes and their reactions are reviewed. Individual syntheses of new heterocycles from indole and isatin oximes… Expand
Quinoline Oximes: Synthesis, Reactions, and Biological Activity
Synthesis and Neurotropic Activity of Novel Quinoline Derivatives
Hydroxyalkyl and carboxyalkyl derivatives of silatetrahydroisoquinoline, tetrahydroisoquinoline and tetrahydroquinoline have been synthesized. Their neurotropic activity has been investigated.
Iron oxide‐based magnetic nanostructures bearing cytotoxic organosilicon molecules for drug delivery and therapy
The results of our own investigation on synthesis, physico-chemical and biological study of iron oxide based magnetic nanoparticles bearing cytotoxic organosilicon molecules of choline and colamine… Expand
Electrochemical oxidation of silatranes
Cyclic voltammetry and voltammetry on a rotating ring-disc electrode have been used for the electrochemical study of silylated cyclic derivatives of triethanolamine—silatranes. Silatranes in… Expand
Water-soluble magnetic nanoparticles with biologically active stabilizers
We present the results of the interaction of iron oxide nanoparticles with some biologically active surfactants, namely, oleic acid and cytotoxic alkanolamine derivatives. Physico-chemical… Expand
Synthesis of cytotoxic derivatives of 2-oxo-1-azetidinylacetamide
New derivatives of 2-oxo-1-azetidinylacetamide have been synthesized by the four-component condensation of β-amino acids with aldehydes and isonitriles. Study of their cytotoxic activity in vitro… Expand
Addition of nitrile oxides to germyl-substituted ethylenes
The reactions of [2+3] cycloaddition of nitrile oxides to mono- and 1,2-disubstituted germylalkenes proceed regioselectively and resulted 5-Ge-substituted isoxazolines-2 from triethylvinyl- and… Expand