• Publications
  • Influence
Natural Sesquiterpene Lactones Induce Oxidative Stress in Leishmania mexicana
TLDR
Results indicate that the induction of oxidative stress is at least one of the mechanisms of action of DhL, Mxc, and Psi on parasites while Psi C would act by another mechanism.
Sesquiterpene lactones and the diterpene 5-epi-icetexone affect the intracellular and extracellular stages of Trypanosoma cruzi.
TLDR
These compounds are very effective against T. cruzi possibly by multiple mechanisms and helenalin was the most potent.
The effect of the diterpene 5-epi-icetexone on the cell cycle of Trypanosoma cruzi.
TLDR
It is concluded that the diterpene 5-epi-icetexone affects the cell cycle of T. cruzi, possibly in the transition S/G2 phase and cell division.
Preparation and antitrypanosomal activity of secochiliolide acid derivatives.
TLDR
The results indicate that the carboxyl group is not essential for the bioactivity of 1, while the presence of the tetrasubstituted exocyclic double bond seems to be important.
Contribution of Microscopy for Understanding the Mechanism of Action Against Trypanosomatids
Transmission electron microscopy (TEM) has proved to be a useful tool to study the ultrastructural alterations and the target organelles of new antitrypanosomatid drugs. Thus, it has been observed
The in vivo trypanocidal effect of the diterpene 5-epi-icetexone obtained from Salvia gilliesii.
TLDR
It is concluded that ICTX has an antiparasitic effect against T. cruzi, thus constituting an interesting option for the treatment of Chagas' disease, alone or combined with other drugs.
An abietane diterpene from Salvia cuspidata and some new derivatives are active against Trypanosoma cruzi.
TLDR
It is concluded that the increase of lipophilicity by chemical modifications is an adequate strategy for improving the trypanocidal activity of this kind abietane diterpenes.
Primary targets of the sesquiterpene lactone deoxymikanolide on Trypanosoma cruzi.
TLDR
Based on the results, deoxymikanolide would exert its anti-T cruzi activity as a strong thiol blocking agent and by producing mitochondrial dysfunction.
Leishmaniasis in the Argentine Republic: Temporal and geographical distribution from 2013 to 2017
TLDR
It is important to analyze the temporal and geographical distribution of leishmaniasis in order to provide an adequate management and surveillance of the disease in the Argentine Republic.
Evaluation of different total Leishmania amazonensis antigens for the development of a first-generation vaccine formulated with a Toll-like receptor-3 agonist to prevent cutaneous leishmaniasis
TLDR
The protein profile and immune response depend on the methodology used to obtain the antigens and the formulation sTLA + Poly (I:C) provides partial protection against cutaneous leishmaniasis in mice.
...
1
2
...