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- Publications
- Influence
Treatment of hereditary tyrosinaemia type I by inhibition of 4-hydroxyphenylpyruvate dioxygenase
- S. Lindstedt, E. Holme, E. Lock, O. Hjalmarson, B. Strandvik
- Medicine
- The Lancet
- 3 October 1992
Liver transplantation is the only effective treatment for hereditary tyrosinaemia type I (McKusick 276700). We have treated one acute and four subacute-chronic cases with… Expand
Cerebellum as a target for toxic substances.
The Purkinje cells and the granule cells are the most important targets in cerebellum for toxic substances. The Purkinje cells are among the largest neuron in the brain and are very sensitive to… Expand
The contributions of excitotoxicity, glutathione depletion and DNA repair in chemically induced injury to neurones: exemplified with toxic effects on cerebellar granule cells
Six chemicals, 2‐halopropionic acids, thiophene, methylhalides, methylmercury, methylazoxymethanol (MAM) and trichlorfon ( Fig. 1 ), that cause selective necrosis to the cerebellum, in particular to… Expand
Chemically Induced Renal Tubule Tumors in the Laboratory Rat and Mouse: Review of the NCI/NTP Database and Categorization of Renal Carcinogens Based on Mechanistic Information
ABSTRACT The incidence of renal tubule carcinogenesis in male and female rats or mice with 69 chemicals from the 513 bioassays conducted to date by the NCI/NTP has been collated, the chemicals… Expand
Trichloroethylene: mechanisms of renal toxicity and renal cancer and relevance to risk assessment.
1,1,2-Trichloroethylene (TCE) is an important solvent that is widespread in the environment. We have reviewed carcinogenicity data from seven bioassays with regard to renal injury and renal tumors.… Expand
Biochemical mechanisms of induction of hepatic peroxisome proliferation.
- E. Lock, A. Mitchell, C. Elcombe
- Biology, Medicine
- Annual review of pharmacology and toxicology
- 1989
The process of xenobiotic-induced proliferation of the cytoplasmic organelle, the peroxisome, in mammalian liver cells has received considerable attention because of the proposed relationship between… Expand
Tissue distribution of 2-(2-nitro-4-trifluoromethylbenzoyl)cyclohexane-1-3-dione (NTBC): effect on enzymes involved in tyrosine catabolism and relevance to ocular toxicity in the rat.
- E. Lock, P. Gaskin, +5 authors L. Mutter
- Biology, Medicine
- Toxicology and applied pharmacology
- 1 December 1996
Administration of a single oral dose of 2-(2-nitro-4-trifluoromethylbenzoyl)cyclohexane-1,3-dione (NTBC) to rats produced a marked tyrosinemia in the plasma and aqueous humor. The tyrosinemia was… Expand
The role of glutathione S-transferase- and cytochrome P450-dependent metabolism in the olfactory toxicity of methyl iodide in the rat
- M. P. Chamberlain, E. Lock, B. Gaskell, C. Reed
- Biology, Medicine
- Archives of Toxicology
- 1 June 1998
Abstract The aim of this study was to investigate the role of metabolic activation in the olfactory toxicity of methyl iodide (MeI). Adult male rats were exposed via nose-only inhalation to 100ppm… Expand
Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione and 2-(2-chloro-4-methanesulfonylbenzoyl)-cyclohexane-1,3-dione.
- M. K. Ellis, A. Whitfield, +4 authors L. Smith
- Chemistry, Medicine
- Toxicology and applied pharmacology
- 1 July 1995
The administration of the compound 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione (NTBC) to rats (10 mg/kg body wt) caused an elevation in the concentration of plasma tyrosine and gave… Expand
Necrosis of the pars recta (S3 segment) of the rat kidney produced by hexachloro 1:3 butadiene
- J. Ishmael, I. Pratt, E. Lock
- Biology, Medicine
- The Journal of pathology
- 1 October 1982
Administration of hexachloro 1 : 3 butadiene (HCBD) intraperitoneally at a dose of 200 mg/kg body weight caused necrosis of the pars recta of the proximal tubules situated in the outer stripe of the… Expand