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Treatment of hereditary tyrosinaemia type I by inhibition of 4-hydroxyphenylpyruvate dioxygenase
Liver transplantation is the only effective treatment for hereditary tyrosinaemia type I (McKusick 276700). We have treated one acute and four subacute-chronic cases withExpand
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Cerebellum as a target for toxic substances.
The Purkinje cells and the granule cells are the most important targets in cerebellum for toxic substances. The Purkinje cells are among the largest neuron in the brain and are very sensitive toExpand
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The contributions of excitotoxicity, glutathione depletion and DNA repair in chemically induced injury to neurones: exemplified with toxic effects on cerebellar granule cells
Six chemicals, 2‐halopropionic acids, thiophene, methylhalides, methylmercury, methylazoxymethanol (MAM) and trichlorfon ( Fig. 1 ), that cause selective necrosis to the cerebellum, in particular toExpand
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Chemically Induced Renal Tubule Tumors in the Laboratory Rat and Mouse: Review of the NCI/NTP Database and Categorization of Renal Carcinogens Based on Mechanistic Information
  • E. Lock, G. Hard
  • Biology, Medicine
  • Critical reviews in toxicology
  • 1 January 2004
ABSTRACT The incidence of renal tubule carcinogenesis in male and female rats or mice with 69 chemicals from the 513 bioassays conducted to date by the NCI/NTP has been collated, the chemicalsExpand
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Trichloroethylene: mechanisms of renal toxicity and renal cancer and relevance to risk assessment.
  • E. Lock, C. Reed
  • Chemistry, Medicine
  • Toxicological sciences : an official journal of…
  • 1 June 2006
1,1,2-Trichloroethylene (TCE) is an important solvent that is widespread in the environment. We have reviewed carcinogenicity data from seven bioassays with regard to renal injury and renal tumors.Expand
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Biochemical mechanisms of induction of hepatic peroxisome proliferation.
The process of xenobiotic-induced proliferation of the cytoplasmic organelle, the peroxisome, in mammalian liver cells has received considerable attention because of the proposed relationship betweenExpand
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Tissue distribution of 2-(2-nitro-4-trifluoromethylbenzoyl)cyclohexane-1-3-dione (NTBC): effect on enzymes involved in tyrosine catabolism and relevance to ocular toxicity in the rat.
Administration of a single oral dose of 2-(2-nitro-4-trifluoromethylbenzoyl)cyclohexane-1,3-dione (NTBC) to rats produced a marked tyrosinemia in the plasma and aqueous humor. The tyrosinemia wasExpand
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The role of glutathione S-transferase- and cytochrome P450-dependent metabolism in the olfactory toxicity of methyl iodide in the rat
Abstract The aim of this study was to investigate the role of metabolic activation in the olfactory toxicity of methyl iodide (MeI). Adult male rats were exposed via nose-only inhalation to 100ppmExpand
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Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione and 2-(2-chloro-4-methanesulfonylbenzoyl)-cyclohexane-1,3-dione.
The administration of the compound 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione (NTBC) to rats (10 mg/kg body wt) caused an elevation in the concentration of plasma tyrosine and gaveExpand
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Necrosis of the pars recta (S3 segment) of the rat kidney produced by hexachloro 1:3 butadiene
Administration of hexachloro 1 : 3 butadiene (HCBD) intraperitoneally at a dose of 200 mg/kg body weight caused necrosis of the pars recta of the proximal tubules situated in the outer stripe of theExpand
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