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CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
- E. Janssen, E. Lemmens, T. Wolfe, U. Christen, M. Herrath, S. Schoenberger
- 20 February 2003
The results demonstrate that T-cell help is ‘programmed’ into CD8+ T cells during priming, conferring on these cells a hallmark of immune response memory: the capacity for functional expansion on re-encounter with antigen.
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity.
Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation
It is found that naïve CTLs become committed after as little as 2 h of exposure to APCs and that their subsequent division and differentiation can occur without the need for further antigenic stimulation of the daughter cells, whether priming is in vitro or in vivo.
CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death
Regulation of Trail expression can account for the role of CD4+ T cells in the generation of CD8+ T cell memory and represents a novel mechanism for controlling adaptive immune responses.
Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer.
- D. Le, A. Wang-Gillam, E. Jaffee
- Medicine, BiologyJournal of clinical oncology : official journal…
- 20 April 2015
Heterologous prime/boost vaccination with Cy/GVAX and CRS-207 extended survival for patients with pancreatic cancer, with minimal toxicity.
STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
The authors modified the cyclic dinucleotides to strengthen their binding to human STING, increasing their antitumor activity and showed that treatment with STINGVAX caused cancer cells to up-regulate PD-L1, a protein that suppresses the immune response.
Dynamic programming of CD8+ T lymphocyte responses
Results show that an instructional program preceding the first cell division integrates differences in signal strength into the decision to activate versus tolerize specific CTL clones.
IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory.
It is proposed that homeostatic control of antiviral CD4(+) and CD8(+) T cell memory is fundamentally similar and characterized by quantitative, rather than qualitative, differences.
Constitutive Activation of the PrfA Regulon Enhances the Potency of Vaccines Based on Live-Attenuated and Killed but Metabolically Active Listeria monocytogenes Strains
It is shown that PrfA*(G155S) enhanced functional cellular immunity following an intravenous or intramuscular prime-boost immunization regimen, form the basis of a rationale for including the prfA(G 155S) allele in future live-attenuated or KBMA L. monocytogenes vaccines advanced to the clinical setting.
Protein Kinase C-θ Is an Early Survival Factor Required for Differentiation of Effector CD8+ T Cells1
It is reported that PKCθ is not required for Ag-inducedCD8+ T cell proliferation, but is important for T cell survival and differentiation into functional, cytokine-producing CTLs, thereby enabling the complete genetic program of effector CD8+ differentiation.