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Rac Homologues and Compartmentalized Phosphatidylinositol 4, 5-Bisphosphate Act in a Common Pathway to Regulate Polar Pollen Tube Growth
Pollen tube cells elongate based on actin- dependent targeted secretion at the tip. Rho family small GTPases have been implicated in the regulation of related processes in animal and yeast cells. WeExpand
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Inactivation of AtRac1 by abscisic acid is essential for stomatal closure.
Plant water homeostasis is maintained by the phytohormone abscisic acid (ABA), which triggers stomatal pore closure in response to drought stress. We identified the Arabidopsis small guanosineExpand
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Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine
Pathogenic Escherichia coli are responsible for a variety of diseases, including diarrhoea, haemolytic uraemic syndrome, kidney infection, septicaemia, pneumonia and meningitis. Toxins calledExpand
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CNF1 Exploits the Ubiquitin-Proteasome Machinery to Restrict Rho GTPase Activation for Bacterial Host Cell Invasion
CNF1 toxin is a virulence factor produced by uropathogenic Escherichia coli. Upon cell binding and introduction into the cytosol, CNF1 deamidates glutamine 63 of RhoA (or 61 of Rac and Cdc42),Expand
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Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia.
The rho family of GTP-binding proteins regulates actin filament organization. In unpolarized mammalian cells, rho proteins regulate the assembly of actin-containing stress fibers at the cell-matrixExpand
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System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
HECT-family E3 ligases ubiquitinate protein substrates to control virtually every eukaryotic process and are misregulated in numerous diseases. Nonetheless, understanding of HECT E3s is limited by aExpand
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The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1.
Rac1 small GTPase controls essential aspects of cell biology and is a direct target of numerous bacterial virulence factors. The CNF1 toxin of pathogenic Escherichia coli addresses Rac1 toExpand
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Rho GTPase-activating bacterial toxins: from bacterial virulence regulation to eukaryotic cell biology.
Studies on the interactions of bacterial pathogens with their host have provided an invaluable source of information on the major functions of eukaryotic and prokaryotic cell biology. In addition,Expand
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Membrane translocation of diphtheria toxin fragment A exploits early to late endosome trafficking machinery
After reaching early endosomes by receptor‐mediated endocytosis, diphtheria toxin (DT) molecules have two possible fates. A large pool enters the degradative pathway whereas a few molecules becomeExpand
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IRSp53 senses negative membrane curvature and phase separates along membrane tubules
BAR domain proteins contribute to membrane deformation in diverse cellular processes. The inverted-BAR (I-BAR) protein IRSp53, for instance, is found on the inner leaflet of the tubular membrane ofExpand
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