• Publications
  • Influence
Distress call reactivation in isolated chicks: a behavioral indicator with high selectivity for antidepressants
  • E. Lehr
  • Psychology, Medicine
  • Psychopharmacology
  • 2004
Four-day-old chicks respond to isolation with distress calling. A decrease in distress calling during isolation seems to reflect some general aspect of depressive syndrome and appears to be sensitiveExpand
  • 26
  • 2
Selective A1-Antagonists for Treatment of Cognitive Deficits
Abstract A novel compound, KFM 19, is introduced, which turned out to be a selective adenosine A1-antagonist with good bioavailability. Its pharmacological profile suggests a high therapeuticExpand
  • 49
  • 1
Testing Antipsychotic Drug Effects with Operant Behavioral Techniques
Operant techniques offer one of the best possible controls of behavior. Depending on the pattern of reinforcement the animals produce characteristic patterns of responding (Ferster and Skinner,Expand
  • 8
Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles ('hetrazepines').
1,4-Diazepines with two annelated heterocycles ('hetrazepines') such as brotizolam (WE 941), WE 973 and WE 1008 bind with high affinities to benzodiazepine receptors in the central nervous system.Expand
  • 20
Pharmacology of WEB 1881-FU, a central cholinergic agent, which enhances cognition and cerebral metabolism.
The pharmacological effects of the novel compound WEB 1881 FU (4-amino-methyl-1-benzyl-pyrrolidine-2-one-fumarate) were investigated. The tests performed indicate that the compound has cytoprotectiveExpand
  • 14
Pharmacology and hypnogenic properties of brotizolam in animals.
Brotizolam differs in pharmacological profile from other diazepines by virtue of its hypnogenic potency. It increases, whereas other diazepines reduce, sleep in the cat. With increasing doses, theExpand
  • 8
Potential antidepressant properties of pramipexole detected in locomotor and operant behavioral investigations in mice
  • E. Lehr
  • Psychology, Medicine
  • Psychopharmacology
  • 29 August 2002
Abstract Rationale. Pramipexole is a dopamine agonist which binds selectivly to dopamine D3 and D2 receptors. There is evidence that, in addition to its beneficial effects in parkinsonism, thisExpand
  • 9
Antiemotional and anticonvulsant activity of brotizolam and its effects on motor performance in animals.
Brotizolam (2-bromo-4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f]-1,2,4-triazolo [4,3-a]-1,4-diazepine, We 941, Lendormin) is a thienotriazolo diazepine with predominantly sleep-inducing properties.Expand
  • 9
Pharmacological action of some known and possible metabolites of brotizolam.
The two major metabolites of brotizolam (2-bromo-4-(2-chlorophenyl)-9-methyl-6H-thieno [3,2-f]-1,2,4-triazolo [4,3-a]-1,4-diazepine, We 941, Lendormin) in man are the hydroxylation products We 964Expand
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General pharmacology of brotizolam in animals.
Brotizolam (2-bromo-4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f]-1,2,4-triazolo [4,3-a]-1,4-diazepine, We 941, Lendormin) is a thienotriazolo-diazepine with profound sedative and hypnogenicExpand
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