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Overexpression of constitutive signal transducer and activator of transcription 3 mRNA in cisplatin-resistant human non-small cell lung cancer cells.
Non-small cell lung cancer (NSCLC) often shows intrinsic multidrug resistance, which is one of the most serious problems in cisplatin-based adjuvant chemotherapy. Recently, the constitutiveExpand
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Expression of multidrug resistance proteins and accumulation of cisplatin in human non-small cell lung cancer cells.
In order to understand and overcome multidrug resistance (MDR) of human non-small cell lung cancer (NSCLC), mRNA and protein expression levels of P-glycoprotein (MDR1), multidrugExpand
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Roles of cathepsins in reperfusion-induced apoptosis in cultured astrocytes
Astrocytic apoptosis may play a role in the central nervous system injury. We previously showed that reperfusion of cultured astrocytes with normal medium after exposure to hydrogen peroxideExpand
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Heat shock inhibits hydrogen peroxide-induced apoptosis in cultured astrocytes
Heat shock proteins (HSPs) have been shown to act as inhibitors of apoptosis, but this anti-apoptotic effect is not known in the central nervous system. Prior heat shock has been demonstrated toExpand
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Activation of adenylate cyclase of rat brain by lipid peroxidation.
The relationship between adenylate cyclase activity in the synaptic membrane fraction (M1) of rat brain and lipid peroxidation of these membranes was examined. In the presence of 5 mM dithiothreitolExpand
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Solubilization of adenylate cyclase of brain membranes by lipid peroxidation.
Adenylate cyclase in the membrane fractions of bovine and rat brains, but not in rat liver plasma membranes, was solubilized by treatment with Fe2+ (10 microM) plus dithiothreitol (5 mM).Expand
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Selective induction of cytochrome b5 and NADH cytochrome b5 reductase by propylthiouracil.
Both the cytochrome b5 level and NADH cytochrome b5 reductase activity in rat liver microsomes were increased 2-fold by repeated i.p. administration of 1.5 mmol/kg propylthiouracil (PTU) for 2 weeks,Expand
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The nitric oxide donor NOC12 protects cultured astrocytes against apoptosis via a cGMP-dependent mechanism.
We examined the effect of 3-ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene (NOC12), a nitric oxide (NO) donor, on apoptosis in cultured astrocytes. Reperfusion after hydrogen peroxide (H2O2)Expand
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Activation of rat brain adenylate cyclase by copper plus dithiothreitol.
Abstract Cu(II), an indispensable metal ion for living cells, is known to oxidize SH groups to disulfide bonds in proteins (1). Many enzymes, such as adenylate cyclase (2–4), phosphodiesterase (5, 6)Expand
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Inhibition of P‐Glycoprotein by Wogonin Is Involved with the Potentiation of Etoposide‐Induced Apoptosis in Cancer Cells
Etoposide induces apoptotic cell death in normal and cancer cells. This apoptosis plays a role not only in anticancer effects but also in adverse reactions, such as myelosuppression. Because we hadExpand
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