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- Publications
- Influence
Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.
- D. M. Bollag, P. A. McQueney, +6 authors C. Woods
- Biology, Medicine
- Cancer research
- 1 June 1995
Tubulin polymerization into microtubules is a dynamic process, with the equilibrium between growth and shrinkage being essential for many cellular processes. The antineoplastic agent taxol… Expand
Intermediate filaments as mechanical integrators of cellular space
- E. Lazarides
- Chemistry, Medicine
- Nature
- 17 January 1980
Five chemically distinct classes of intermediate filaments can be identified within higher eukaryotic cells. Each class is characteristic of a particular cell type. These filaments may function to… Expand
Intermediate filaments: a chemically heterogeneous, developmentally regulated class of proteins.
- E. Lazarides
- Biology, Medicine
- Annual review of biochemistry
- 1982
Perspectives and Summary .... . . . . , . Keratin Filaments: A Family oj Proteins . .. . . . .. . . . ... . . . . . . . . . . . . . . . . . . . . . . . . . ... . . . . . . . . . . . . . . . . . . . .… Expand
Actin is the naturally occurring inhibitor of deoxyribonuclease I.
- E. Lazarides, U. Lindberg
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 December 1974
Various tissues and cells in culture contain a specific inhibitor of DNase I (EC 3.1.4.5). In this paper evidence is presented that this inhibitor is actin, one of the major structural proteins of… Expand
Synemin: a new high molecular weight protein associated with desmin and vimentin filaments in muscle
- B. L. Granger, E. Lazarides
- Biology, Medicine
- Cell
- 1 December 1980
A 230,000 dalton polypeptide co-purifies through cycles of depolymerization and polymerization with the intermediate filament subunits, desmin and vimentin, from avian smooth muscle. This protein is… Expand
Membrane skeletal protein 4.1 of avian erythrocytes is composed of multiple variants that exhibit tissue-specific expression
- B. Granger, E. Lazarides
- Biology, Medicine
- Cell
- 1 June 1984
The avian analog of mammalian erythrocyte protein 4.1, a structural component of the membrane skeleton, has been identified. It is present at the plasma membranes of avian erythrocytes and lens… Expand
α-Actinin: Immunofluorescent localization of a muscle structural protein in nonmuscle cells
- E. Lazarides, K. Burridge
- Biology, Medicine
- Cell
- 1 November 1975
Antibodies specific for the skeletal muscle structural protein alpha-actinin are used to localize this protein by indirect immunofluorescence in nonmuscle cells. In cultured nonmuscle cells,… Expand
The synthesis and distribution of desmin and vimentin during myogenesis in vitro
- D. Gard, E. Lazarides
- Biology, Medicine
- Cell
- 31 January 1980
Electrophoretic and autoradiographic analyses of the incorporation of 35S--methionine into newly synthesized proteins during myogenesis reveal that presumptive chicken myoblasts synthesize primarily… Expand
Actin, alpha-actinin, and tropomyosin interaction in the structural organization of actin filaments in nonmuscle cells
- E. Lazarides
- Medicine, Biology
- The Journal of cell biology
- 1 February 1976
During the spreading of a population of rat embryo cells, approximately 40% of the cells develop a strikingly regular network which precedes the formation of the straight actin filament bundles seen… Expand
Widespread occurrence of avian spectrin in nonerythroid cells
- E. Repasky, B. Granger, E. Lazarides
- Biology, Medicine
- Cell
- 1 July 1982
We have prepared an antibody against chicken erythrocyte alpha spectrin, using as immunogen protein purified by two-dimensional polyacrylamide gel electrophoresis. One- and two-dimensional… Expand