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Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.
Tubulin polymerization into microtubules is a dynamic process, with the equilibrium between growth and shrinkage being essential for many cellular processes. The antineoplastic agent taxolExpand
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Intermediate filaments as mechanical integrators of cellular space
Five chemically distinct classes of intermediate filaments can be identified within higher eukaryotic cells. Each class is characteristic of a particular cell type. These filaments may function toExpand
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Intermediate filaments: a chemically heterogeneous, developmentally regulated class of proteins.
  • E. Lazarides
  • Biology, Medicine
  • Annual review of biochemistry
  • 1982
Perspectives and Summary .... . . . . , . Keratin Filaments: A Family oj Proteins . .. . . . .. . . . ... . . . . . . . . . . . . . . . . . . . . . . . . . ... . . . . . . . . . . . . . . . . . . . .Expand
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Actin is the naturally occurring inhibitor of deoxyribonuclease I.
Various tissues and cells in culture contain a specific inhibitor of DNase I (EC 3.1.4.5). In this paper evidence is presented that this inhibitor is actin, one of the major structural proteins ofExpand
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Synemin: a new high molecular weight protein associated with desmin and vimentin filaments in muscle
A 230,000 dalton polypeptide co-purifies through cycles of depolymerization and polymerization with the intermediate filament subunits, desmin and vimentin, from avian smooth muscle. This protein isExpand
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Membrane skeletal protein 4.1 of avian erythrocytes is composed of multiple variants that exhibit tissue-specific expression
The avian analog of mammalian erythrocyte protein 4.1, a structural component of the membrane skeleton, has been identified. It is present at the plasma membranes of avian erythrocytes and lensExpand
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α-Actinin: Immunofluorescent localization of a muscle structural protein in nonmuscle cells
Antibodies specific for the skeletal muscle structural protein alpha-actinin are used to localize this protein by indirect immunofluorescence in nonmuscle cells. In cultured nonmuscle cells,Expand
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The synthesis and distribution of desmin and vimentin during myogenesis in vitro
Electrophoretic and autoradiographic analyses of the incorporation of 35S--methionine into newly synthesized proteins during myogenesis reveal that presumptive chicken myoblasts synthesize primarilyExpand
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Actin, alpha-actinin, and tropomyosin interaction in the structural organization of actin filaments in nonmuscle cells
  • E. Lazarides
  • Medicine, Biology
  • The Journal of cell biology
  • 1 February 1976
During the spreading of a population of rat embryo cells, approximately 40% of the cells develop a strikingly regular network which precedes the formation of the straight actin filament bundles seenExpand
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Widespread occurrence of avian spectrin in nonerythroid cells
We have prepared an antibody against chicken erythrocyte alpha spectrin, using as immunogen protein purified by two-dimensional polyacrylamide gel electrophoresis. One- and two-dimensionalExpand
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