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Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage.
DNA damage generated by oxidant byproducts of cellular metabolism has been proposed as a key factor in cancer and aging. Oxygen free radicals cause predominantly base damage in DNA, and the mostExpand
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Progression of kidney dysfunction in the community-dwelling elderly.
Despite the high prevalence of chronic kidney disease among the elderly, few studies have described their loss of kidney function. We sought to determine the progression of kidney dysfunction among aExpand
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Assisted reproduction in male cancer survivors: fertility treatment and outcome in 67 couples.
BACKGROUND Many male cancer survivors experience fertility problems due to antineoplastic treatment. We report the fertility outcome in 67 couples referred to assisted reproduction treatment (ART)Expand
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Proliferation Failure and Gamma Radiation Sensitivity of Fen1 Null Mutant Mice at the Blastocyst Stage
ABSTRACT Flap endonuclease 1 (FEN1) has been shown to remove 5′ overhanging flap intermediates during base excision repair and to process the 5′ ends of Okazaki fragments during lagging-strand DNAExpand
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ALKBH1 Is a Histone H2A Dioxygenase Involved in Neural Differentiation
AlkB homolog 1 (ALKBH1) is one of nine members of the family of mammalian AlkB homologs. Most Alkbh1−/− mice die during embryonic development, and survivors are characterized by defects in tissuesExpand
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Kinetics of endogenous mouse FEN1 in base excision repair
The structure specific flap endonuclease 1 (FEN1) plays an essential role in long-patch base excision repair (BER) and in DNA replication. We have generated a fluorescently tagged FEN1 expressingExpand
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Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells.
Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded trinucleotide CAG repeat in the Huntingtin (Htt) gene. The molecular basis for the development and progression of HD isExpand
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Transcription activities at 8-oxoG lesions in DNA.
7,8-Dihydro-8-oxoguanine (8-oxoG) is the most frequent mutagenic lesion caused by oxidative stress. Eukaryotic cells use a specific DNA glycosylase, OGG1, to excise 8-oxoG from DNA. The mildExpand
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Continuous and Periodic Expansion of CAG Repeats in Huntington's Disease R6/1 Mice
Huntington's disease (HD) is one of several neurodegenerative disorders caused by expansion of CAG repeats in a coding gene. Somatic CAG expansion rates in HD vary between organs, and the greatestExpand
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Repair and mutagenesis at oxidized DNA lesions in the developing brain of wild-type and Ogg1−/− mice
OGG1 (8-oxoguanine DNA glycosylase-1) is one of the main DNA glycosylases present in mammalian cells. The enzyme removes 7,8-dihydro-8-oxoguanine (8-oxoG) lesions, believed to be the most importantExpand
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