Aaptamine and related products. Their isolation, chemical syntheses, and biological activity.
- E. Larghi, M. Bohn, T. Kaufman
- Chemistry
- 30 May 2009
The intermolecular Pictet-Spengler condensation with chiral carbonyl derivatives in the stereoselective syntheses of optically-active isoquinoline and indole alkaloids
- E. Larghi, Marcela Amongero, Andrea B. J. Bracca, T. Kaufman
- Chemistry
- 19 October 2005
The stereoselective Pictet-Spengler synthesis is one of the currently most important synthetic methodologies for the preparation of polysubstituted optically active tetrahydroisoquinolines and…
Synthesis of Oxacycles Employing the Oxa-Pictet–Spengler Reaction: Recent Developments and New Prospects†
- E. Larghi, T. Kaufman
- Chemistry
- 1 September 2011
The oxa-Pictet–Spengler cyclization is the oxygen variation of the Pictet–Spengler reaction, in which an aromatic alcohol component (generally a β-arylethyl alcohol) reacts with acarbonyl component…
Synthesis of symmetrically substituted 3,3-dibenzyl-4-hydroxy-3,4-dihydro-1H-quinolin-2-ones, as novel quinoline derivatives with antibacterial activity.
- M. Ferretti, Alexandre T. Neto, A. Morel, T. Kaufman, E. Larghi
- ChemistryEuropean journal of medicinal chemistry
- 23 June 2014
Neocryptolepine (Cryprotackieine), A Unique Bioactive Natural Product: Isolation, Synthesis, and Profile of Its Biological Activity
- Andrea B. J. Bracca, Daniel A. Heredia, E. Larghi, T. Kaufman
- Chemistry
- 1 December 2014
The widely varying different approaches to the total synthesis of the indoloquinoline alkaloid neocryptolepine are discussed. Aspects relating to the isolation of the natural product from Cryptolepis…
Angular tricyclic benzofurans and related natural products of fungal origin. Isolation, biological activity and synthesis.
- Sebastián O. Simonetti, E. Larghi, Andrea B. J. Bracca, T. Kaufman
- ChemistryNatural product reports (Print)
- 10 June 2013
Naturally-occurring angular tricyclic benzofuran/isobenzofuran derivatives of fungal origin and related compounds, in which two heterocyclic rings are fused to a central benzenoid moiety, are…
The 3,4-dioxygenated 5-hydroxy-4-aryl-quinolin-2(1H)-one alkaloids. Results of 20 years of research, uncovering a new family of natural products.
- Sebastián O. Simonetti, E. Larghi, T. Kaufman
- ChemistryNatural product reports (Print)
- 23 November 2016
The small but steadily growing family of the naturally occurring 5-hydroxy-4-aryl-quinolin-2(1H)-one alkaloids and closely related compounds, which represent the results of various research projects that spanned over 20 years and involved scientists from different continents, are covered here.
Total Synthesis of Waltherione F, a Nonrutaceous 3-Methoxy-4-quinolone, Isolated from Waltheria indica L. F.
- Abel A Arroyo Aguilar, Santiago J Bolívar Avila, T. Kaufman, E. Larghi
- ChemistryOrganic Letters
- 6 August 2018
Waltherione F was totally synthesized in seven steps and 31% overall yield from 2-nitro-3-methylanisole without the use of protecting groups. Key steps in the sequence were a Suzuki-Miyaura coupling…
A formal total synthesis of the marine alkaloid aaptamine
- E. Larghi, Blaise V. Obrist, T. Kaufman
- Chemistry
- 26 May 2008
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