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Evidence of the Indirect Formation of the Catecholic Intermediate Substrate Responsible for the Autoactivation Kinetics of Tyrosinase*
Tyrosinase (EC 1.14.18.1) exhibits unusual kinetic properties in the oxidation of monohydric phenol substrates consisting of a lag period that increases with increasing substrate concentration. TheExpand
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Bipyridylium quaternary salts and related compounds. V. Pulse radiolysis studies of the reaction of paraquat radical with oxygen. Implications for the mode of action of bipyridyl herbicides.
1. Rate constants for reduction of paraquat ion (1,1′-dimethyl-4,4′-bipyridy-lium, PQ2+) to paraquat radical (PQ+·) by e−aq and CO2−· have been measured by pulse radiolysis. Reduction by e−aq isExpand
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Reactions of nitrogen dioxide in aqueous model systems: oxidation of tyrosine units in peptides and proteins.
By application of pulse radiolysis it was demonstrated that nitrogen dioxide (NO2.) oxidizes Gly-Tyr in aqueous solution with a strongly pH-dependent rate constant (k6 = 3.2 X 10(5) M-1 S-1 at pH 7.5Expand
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Singlet oxygen quenching and the redox properties of hydroxycinnamic acids.
The singlet oxygen quenching rate constants (kq) for a range of hydroxycinnamic acids in acetonitrile and D2O solutions were measured using time resolved near infrared phosphorescence in order toExpand
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A pulse radiolysis investigation of the oxidation of the melanin precursors 3,4-dihydroxyphenylalanine (dopa) and the cysteinyldopas.
The unstable quinones of 3,4-dihydroxyphenylalanine (dopa) and the most abundant cysteinyldopa isomers (2S-, 5S- and 2,5S,S'-) have been generated rapidly via disproportionation of their respectiveExpand
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The mechanism of suicide-inactivation of tyrosinase: a substrate structure investigation.
Tyrosinase is a copper-containing mono-oxygenase, widely distributed in nature, able to catalyze the oxidation of both phenols and catechols to the corresponding ortho-quinones. Tyrosinase isExpand
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Quinone chemistry and melanogenesis.
Publisher Summary The divergence of the melanogenic pathway occurs after the initial oxidation step that yields dopaquinone. The current analytical approach to the classification of melanins dependsExpand
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Spontaneous redox reactions of dopaquinone and the balance between the eumelanic and phaeomelanic pathways.
Eumelanogenesis and phaeomelanogenesis diverge at an early stage in pigment formation, namely at the point where dopaquinone, the initial product of tyrosine oxidation by tyrosinase, undergoes one ofExpand
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Flash Photolysis and Pulse Radiolysis: Contributions to the Chemistry of Biology and Medicine
How can you change your mind to be more open? There many sources that can help you to improve your thoughts. It can be from the other experiences and also story from some people. Book is one of theExpand
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