• Publications
  • Influence
Controlled cell death, plant survival and development
  • E. Lam
  • Biology, Medicine
    Nature Reviews Molecular Cell Biology
  • 1 April 2004
Recent genetic, molecular and biochemical approaches have begun to reveal interesting candidate regulators in plants that show both similar and new properties compared with their animal counterparts.
NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid.
The results directly link NPR1 to SA-induced PR-1 expression through members of the TGA family of transcription factors through the interaction of NPR1 with TGA2 and TGA3.
Morphological classification of plant cell deaths
A classification based on morphological criteria is suggested of PCD associated with the hypersensitive response to biotrophic pathogens, which can express features of both necrosis and vacuolar cell death, PCD in starchy cereal endosperm and during self-incompatibility.
Programmed cell death, mitochondria and the plant hypersensitive response
Many of the cell-death regulators that have been characterized in humans, worms and flies are absent from the Arabidopsis genome, indicating that plants probably use other regulators to control this process.
Two tobacco DNA-binding proteins with homology to the nuclear factor CREB
THE 35S promoter of the cauliflower mosaic virus (CaMV) contains a tandem repeat of the sequence TGACG in the region −83 to −63. This 21-base pair (bp) sequence, called as-1, is involved in root
BAX Inhibitor-1 Modulates Endoplasmic Reticulum Stress-mediated Programmed Cell Death in Arabidopsis*
It is proposed that AtBI1 plays a pivotal role as a highly conserved survival factor during ER stress that acts in parallel to the unfolded protein response pathway.
Nitric oxide and salicylic acid signaling in plant defense.
It is demonstrated that increases in NO synthase (NOS)-like activity occurred in resistant but not susceptible tobacco after infection with tobacco mosaic virus, and this increase in activity participates in PR-1 gene induction.
Site-specific mutations alter in vitro factor binding and change promoter expression pattern in transgenic plants.
A single factor binding site that is defined by site-specific mutations is shown to be sufficient to alter the expression pattern of promoters in vivo.
Activation of hsr203, a plant gene expressed during incompatible plant-pathogen interactions, is correlated with programmed cell death.
A strong correlation between hsr203 and genetically controlled cell death in tobacco and tomato is demonstrated and the expression of this gene should be a useful marker for programmed cell death occurring in response not only to diverse pathogens, but also to diverse death-triggering extracellular agents.
Phytotoxicity and Innate Immune Responses Induced by Nep1-Like Proteins[W]
The findings strongly suggest that NLP-induced necrosis requires interaction with a target site that is unique to the extracytoplasmic side of dicot plant plasma membranes.