• Publications
  • Influence
Direct Action of Estradiol on Gonadotropin-Releasing Hormone-1 Neuronal Activity via a Transcription-Dependent Mechanism
TLDR
Calcium imaging is used to monitor intracellular calcium oscillations in GnRH-1 neurons maintained in nasal explants and shows that, via ERβ, E2 can rapidly act as a hormone-activated transcription complex and is the first to show that E2 directly increases Gn RH-1 neuronal activity and synchronization.
A Cryptic Site of Vulnerability on the Receptor Binding Domain of the SARS-CoV-2 Spike Glycoprotein
TLDR
It is reported that this first-ever resolution of a human antibody in complex with SARS-CoV-2 and the broad reactivity of this set of antibodies to a conserved betacoronavirus epitope will allow antigenic assessment of vaccine candidates, and provide a framework for accelerated vaccine, immunotherapeutic and diagnostic strategies against Sars-Cov-2.
Serologic Evidence of Fruit Bat Exposure to Filoviruses, Singapore, 2011–2016
TLDR
To determine whether fruit bats in Singapore have been exposed to filoviruses, serum samples from bats of 3 species are screened by using a multiplex assay that detects antibodies against filovIRuses, indicating filovirus circulation among bats in Southeast Asia.
Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus
TLDR
The ephrin entry receptor usage of Cedar virus (CedV), a related henipavirus with unknown zoonotic potential that is nonpathogenic in animals known to be susceptible to Nipah and Hendra disease, is characterized and implicates additional ephrine receptors in potential zoonosis.
Durability of SARS-CoV-2-specific T cell responses at 12-months post-infection
TLDR
The data show that SARS-CoV-2 infection induces polyfunctional memory T cells detectable at 12-months post-infection, with higher frequency noted in those who originally experienced severe disease.
Filovirus-reactive antibodies in humans and bats in Northeast India imply zoonotic spillover
TLDR
This work presents evidence for prior exposure of bat harvesters and two resident fruit bat species to filovirus surface glycoproteins by screening sera in a multiplexed serological assay and indicates circulation of several filoviruses in bats and the possibility for filov virus transmission from bats to humans.
Enhanced Autophagy Contributes to Reduced Viral Infection in Black Flying Fox Cells
TLDR
Improvement of basal and virus-induced autophagy in bat cells connects related reports that long-lived species possess homeostatic processes that dampen oxidative stress and macromolecule damage, enabling bats to serve as natural hosts to an assortment of pathogenic viruses.
Rescue and characterization of recombinant cedar virus, a non-pathogenic Henipavirus species
TLDR
The recombinant Cedar virus platform may be utilized to characterize the determinants of pathogenesis across the henipaviruses, investigate their receptor tropisms, and identify novel pan-henipavirus antivirals.
Host cell virus entry mediated by Australian bat lyssavirus G envelope glycoprotein occurs through a clathrin-mediated endocytic pathway that requires actin and Rab5
TLDR
The requirement of Rab5 for productive infection indicates that ABLV G-mediated fusion occurs within the early endosome compartment, and the predominant pathway utilized by A BLV for internalization into HEK293T cells is clathrin-and actin-dependent.
Rousettus aegyptiacus Bats Do Not Support Productive Nipah Virus Replication
TLDR
It is concluded that EFBs are not an appropriate organism to model NiV infection or transmission in bats, and despite using a conserved target for viral entry, NiV replication is limited in some bat species.
...
1
2
3
4
5
...