• Publications
  • Influence
Central leptin modulates behavioral and neural responsivity to CCK.
The mechanisms through which leptin, the protein product of the ob gene, affects food intake remain to be determined. To assess whether the actions of leptin depend on modulation of within-mealExpand
  • 217
  • 10
  • PDF
Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake
  • S. Gao, K. Kinzig, +13 authors T. Moran
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 30 October 2007
Hypothalamic fatty acid metabolism has recently been implicated in the controls of food intake and energy homeostasis. We report that intracerebroventricular (ICV) injection of leptin, concomitantExpand
  • 191
  • 10
  • PDF
A role for NPY overexpression in the dorsomedial hypothalamus in hyperphagia and obesity of OLETF rats.
Otsuka Long-Evans Tokushima Fatty (OLETF) rats lacking CCK-A receptors are hyperphagic, obese, and diabetic. We have previously demonstrated that these rats have a peripheral satiety deficitExpand
  • 144
  • 7
  • PDF
Running wheel activity prevents hyperphagia and obesity in Otsuka long-evans Tokushima Fatty rats: role of hypothalamic signaling.
Otsuka Long-Evans Tokushima fatty (OLETF) rats lacking cholecystokinin-A receptors are hyperphagic, obese, and diabetic. Although exercise attenuates OLETF rats' obesity, the mechanisms underlyingExpand
  • 134
  • 6
  • PDF
Capsaicin pretreatment attenuates suppression of food intake by cholecystokinin.
Capsaicin, the pungent principal in red pepper, has been shown to damage small-diameter peptide-containing sensory neurons. Suppression of feeding by cholecystokinin octapeptide (CCK OP) wasExpand
  • 178
  • 5
Intracerebroventricular CART peptide reduces food intake and alters motor behavior at a hindbrain site.
Peptides from cocaine- and amphetamine-regulated transcript (CART) reduce food intake in rats when injected into the lateral ventricle. Hypothalamic and hindbrain sites important in the control ofExpand
  • 87
  • 5
  • PDF
Factors contributing to obesity in bombesin receptor subtype-3-deficient mice.
Mice with a targeted disruption of bombesin receptor subtype-3 (BRS-3 KO) develop hyperphagia, obesity, hypertension, and impaired glucose metabolism. However, the factors contributing to theirExpand
  • 46
  • 5
  • PDF
Liraglutide and obesity: a review of the data so far
  • E. Ladenheim
  • Medicine
  • Drug design, development and therapy
  • 30 March 2015
The prevalence of obesity worldwide has nearly doubled since 1980 with current estimates of 2.1 billion in 2013. Overweight and obesity lead to numerous adverse conditions including type 2 diabetes,Expand
  • 58
  • 5
  • PDF
Peptide YY(3-36) inhibits gastric emptying and produces acute reductions in food intake in rhesus monkeys.
Peptide YY3-36 [PYY(3-36)], a gastrointestinal peptide that is released into the circulation in response to ingesting a meal, has recently been suggested to play a role in controlling food intake.Expand
  • 174
  • 4
  • PDF
Disruptions in feeding and body weight control in gastrin-releasing peptide receptor deficient mice.
Bombesin (BN) interacts with two mammalian receptor subtypes termed gastrin-releasing peptide (GRP)-preferring (GRP-R) and neuromedin B (NMB)-preferring (NMB-R) that may mediate the satiety action ofExpand
  • 66
  • 4
  • PDF