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Role of Akt/protein kinase B in metabolism
Since its discovery more than a decade ago, the Ser/Thr kinase Akt/PKB (protein kinase B) has been recognized as being remarkably well conserved across a broad range of species and involved in aExpand
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Trafficking of Crumbs3 during cytokinesis is crucial for lumen formation.
Although lumen generation has been extensively studied through so-called cyst-formation assays in Madin-Darby canine kidney (MDCK) cells, an underlying mechanism that leads to the initial appearanceExpand
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Activation of SOCS-3 by Resistin
ABSTRACT Resistin is an adipocyte hormone that modulates glucose homeostasis. Here we show that in 3T3-L1 adipocytes, resistin attenuates multiple effects of insulin, including insulin receptor (IR)Expand
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Mammalian Lin-7 Stabilizes Polarity Protein Complexes*
Mammalian Lin-7 forms a complex with several proteins, including PALS1, that have a role in polarity determination in epithelial cells. In this study we have found that loss of Lin-7 protein from theExpand
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The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexes
In epithelial cells, the tight junction divides the plasma membrane into distinct apical and basolateral domains. Polarization is essential for epithelial cell function, and apico-basal cell polarityExpand
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Crumbs3 Is Essential for Proper Epithelial Development and Viability
ABSTRACT First identified in Drosophila, the Crumbs (Crb) proteins are important in epithelial polarity, apical membrane formation, and tight junction (TJ) assembly. The conserved Crb intracellularExpand
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tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre
tGolgin-1 (trans-Golgi p230, golgin-245) is a member of a family of large peripheral membrane proteins that associate with the trans-Golgi network (TGN) via a C-terminal GRIP domain. Some GRIP-domainExpand
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Induction of Ran GTP drives ciliogenesis
Recent work suggests an important role for the Ran importin system in cilia trafficking. At the onset of ciliogenesis, Ran GTP levels rise markedly at the centrosome. Altering Ran GTP levels byExpand
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Design challenges for hemoproteins: the solution structure of apocytochrome b5.
In order to characterize the structural and dynamic factors that determine the assembly in b hemoproteins, the solution structure of the 98-residue protein apocytochrome b5 was determined by NMRExpand
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Platelet-derived growth factor (PDGF) stimulates glucose transport in 3T3-L1 adipocytes overexpressing PDGF receptor by a pathway independent of insulin receptor substrates.
Insulin is unique among growth factors and hormones in its ability to control metabolic functions such as the stimulation of glucose uptake and glucose transporter (GLUT4) translocation inExpand
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