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Systematic determination of patterns of gene expression during Drosophila embryogenesis
Analyzing gene-expression patterns by in situ hybridization to whole-mount embryos provides an extremely rich dataset that can be used to identify genes involved in developmental processes that have been missed by traditional genetic analysis.
Global analysis of patterns of gene expression during Drosophila embryogenesis
Nearly 60% of the genes with detectable expression exhibit broad patterns reflecting quantitative rather than qualitative differences between tissues, and the expression patterns of over 1,500 of these genes are documented here for the first time.
An MMP liberates the Ninjurin A ectodomain to signal a loss of cell adhesion.
The identification of NijA, a transmembrane protein whose vertebrate homologs regulate cell adhesion, as a two-hybrid binding partner for Mmp1 is reported, suggesting that tracheal cellAdhesion is regulated by a novel mechanism utilizing an MMP and a ninjurin family member.
T cell-derived glucosteroid response-modifying factor (GRMFT): a unique lymphokine made by normal T lymphocytes and a T cell hybridoma.
Mouse spleen cells and a murine T cell hybridoma, FS6 14.13.1, produce a glucosteroid response-modifying factor (GRMFT) after stimulation with concanavalin A, and GRMFT appears to be distinct from other well-characterized T cell-derived factors.
Examples of interesting observations from this project
Three adjacent Brachyury/T-box genes show remarkably similar expression patterns at cellular blastoderm and are located next to each other on the chromosome (d).