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AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle.
TLDR
Evidence is provided that decreases in muscle content of malonyl-CoA can increase the rate of fatty acid oxidation, and perfusion with medium containing AICAR was found to activate AMPK in skeletal muscle, inactivate ACC, and decrease malony l-coA.
Adenosine increases interleukin 6 release and decreases tumour necrosis factor release from rat adrenal zona glomerulosa cells, ovarian cells, anterior pituitary cells, and peritoneal macrophages.
TLDR
In immune and endocrine tissues, adenosine increases IL-6 release, but inhibits TNF release, which is similar to that of an A2 agonist.
Effects of PTK787/ZK222584, a tyrosine kinase inhibitor, on the growth of a poorly differentiated thyroid carcinoma: an animal study.
TLDR
Results showed that VEGF receptor blockade is a rational approach to the therapy of thyroid cancer, especially for poorly differentiated thyroid cancers with limited or no response to conventional therapy.
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle.
TLDR
Evidence is provided that decreases in muscle content of malonyl-CoA can increase the rate of fatty acid oxidation, and perfusion with medium containing AICAR was found to activate AMPK in skeletal muscle, inactivate ACC, and decrease malony l-coA.
Mechanisms of apoptosis after ischemia and reperfusion: Role of the renin-angiotensin system
TLDR
The data suggest that the RAS plays a pivotal role in cardiac apoptosis which is the early and predominant form of death in myocardial infarction.
Influence of malonyl-CoA and palmitate concentration on rate of palmitate oxidation in rat muscle.
TLDR
Results provide additional evidence that malonyl-CoA is an important regulator of the rate of fatty acid oxidation at palmitate concentrations in the physiological range.
Increase of fibronectin and osteopontin in porcine hearts following ischemia and reperfusion
TLDR
The hypothesis that acute ischemia (2 h), followed by reperfusion (4 h) may induce early OPN and fibronectin in an isolated hemoperfused working porcine heart model is tested and the early appearance of the MMPs (increased collagen degrading enzymes) and PICP (a collagen synthesis marker) following ischemias and reperfusions is demonstrated.
Expression of vascular endothelial growth factor and receptor tyrosine kinases in cardiac ischemia/reperfusion injury.
rate of palmitate oxidation in rat muscle Influence of malonyl-CoA and palmitate concentration on
TLDR
The Journal of applied physiology publishes original papers that deal with diverse area of research in applied physiology, especially those papers emphasizing adaptive and integrative mechanisms.