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Chemotactic Peptide N-formyl-Met-Leu-Phe Activation of p38 Mitogen-activated Protein Kinase (MAPK) and MAPK-activated Protein Kinase-2 in Human Neutrophils*
Activation of polymorphonuclear leukocytes (PMN) by chemotactic peptides initiates a series of functional responses that serve to eliminate pathogens. The intermediate steps that link engagement ofExpand
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Induction of Tyrosine Phosphorylation and Na+/H+Exchanger Activation during Shrinkage of Human Neutrophils*
The ubiquitous isoform of the Na+/H+ exchanger (NHE1) is essential for the regulation of cellular volume. The underlying molecular mechanism, which is poorly understood, was studied in humanExpand
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Osmotic Stimulation of the Na+/H+ Exchanger NHE1: Relationship to the Activation of Three MAPK Pathways
Abstract. The Na+/H+ exchanger (NHE) becomes activated by hyperosmolar stress, thereby contributing to cell volume regulation. The signaling pathway(s) responsible for the shrinkage-inducedExpand
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Loading pyranine via purinergic receptors or hypotonic stress for measurement of cytosolic pH by imaging.
Although used extensively for the measurement of intracellular pH, derivatives of fluorescein such as 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF) have suboptimal sensitivity and canExpand
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Suppressive effects of adenosine on the 5‐lipoxygenase pathway in human polymorphonuclear leukocytes
Leukotrienes are potent mediators of inflammation and host defense. They are also involved in inflammatory and allergic diseases. While numerous studies have investigated the stimulatory mechanismsExpand
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The synthesis of leukotrienes by the human neutrophil
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Loading pyranine via purinergic receptors or hypotonic stress for measurement of cytosolic pH by imaging.
Although used extensively for the measurement of intracellular pH, derivatives of fluorescein such as 2', 7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF) have suboptimal sensitivity and canExpand
Enhancement of human neutrophil leukotriene synthesis by human granulocyte-macrophage colony-stimulating factor
Colony-stimulating factors (CSF's), a group of cytokines derived from activated T lymphocytes, macrophages, fibroblasts and endothelial cells, are involved in the proliferation and maturation ofExpand
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