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The GABAB receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats
Abstract GABA systems have been implicated as targets for ethanol at the cellular, molecular and behavioural level. The present study was designed to further examine the potential of the GABAB… Expand
The GABA(B) receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats.
GABA systems have been implicated as targets for ethanol at the cellular, molecular and behavioural level. The present study was designed to further examine the potential of the GABA(B) receptor as a… Expand
Presynaptic adenosine A2a receptors on soma and central terminals of rat vagal afferent neurons
The dorsal vagal complex of the medulla oblongata is a key centre involved in the regulation of numerous autonomic functions, including cardiovascular control. Adenosine has been implicated as a… Expand
Comparison of guinea pig uterine and rat vas deferens preparations for assessment of beta 2-adrenoceptor-mediated activity.
In the present study, investigations were performed to determine the subtype(s) of beta-receptor-mediating relaxation in K+-depolarized guinea pig uterine preparations, and inhibition of twitches in… Expand
Assessing appetitive and consummatory phases of ethanol self-administration in C57BL/6J mice under operant conditions: regulation by mGlu5 receptor antagonism
RationaleThe development of mouse models of ethanol consumption and ethanol-seeking behavior is of particular importance in understanding the underlying mechanisms of drug abuse because these models… Expand
EFFECTS OF PHENOXYBENZAMINE ON RESPONSES TO SOME RECEPTOR AGONISTS AND CALCIUM IN VITRO
- G. McPherson, E. Krstew, E. Malta
- Chemistry, Medicine
- Clinical and experimental pharmacology…
- 1 October 1985
1. Noradrenaline‐induced contractions of the rabbit and rat isolated aorta and guinea‐pig spleen strips were inhibited by concentrations of phenoxybenzamine which did not affect responses to calcium.… Expand
Electrophysiological responses of angiotensin peptides on the rat isolated nodose ganglion.
- R. Widdop, E. Krstew, B. Jarrott
- Biology, Medicine
- Clinical and experimental hypertension. Part A…
Previous autoradiographic studies have identified angiotensin II (AII) binding sites over the nodose ganglion and along the vagal afferent neurons. In the present study, we examined whether these… Expand
Temperature dependence of angiotensin II-mediated depolarisation of the rat isolated nodose ganglion.
The ability of angiotensin II (A II) and 5-hydroxytryptamine (5-HT) to depolarise the rat isolated nodose ganglion preparation was examined. 5-HT depolarised the nodose ganglion, both at room… Expand
Electrophysiological and autoradiographical evidence for cholecystokinin A receptors on rat isolated nodose ganglia.
- R. Widdop, E. Krstew, L. Mercer, M. Carlberg, P. Beart, B. Jarrott
- Biology, Medicine
- Journal of the autonomic nervous system
The sulphated octapeptide, cholecystokinin (CCK-8S), is believed to be a neurotransmitter of vagal sensory neurones, and here the presence of functional receptors for CCK-8S in the rat vagus nerve… Expand
Changes in function and ultrastructure of striatal dopaminergic terminals that regenerate following partial lesions of the SNpc
Following partial substantia nigra lesions, remaining dopaminergic neurones sprout, returning terminal density in the dorsal striatum to normal by 16 weeks. This suggests regeneration and maintenance… Expand