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Development of heart failure following isoproterenol administration in the rat: role of the renin-angiotensin system.
OBJECTIVE High dosages of catecholamines induce cardiomyocyte necrosis and interstitial fibrosis in rats. We investigated whether this initial damage is followed by the development of heart failure… Expand
31P Magnetic Resonance Spectroscopy in Dilated Cardiomyopathy and Coronary Artery Disease: Altered Cardiac High‐Energy Phosphate Metabolism in Heart Failure
BackgroundThe purpose of this work was to further define the value of cardiac 31P magnetic resonance (MR) spectroscopy for patients with coronary artery disease and dilated cardiomyopathy. Methods… Expand
Myocardial hypertrophy and enhanced left ventricular contractility in Zucker diabetic fatty rats.
- S. Fredersdorf, Christian Thumann, +5 authors Joachim Weil
- Cardiovascular pathology : the official journal…
Heart failure is known to be a complication of insulin-dependent (IDDM) and noninsulin-dependent diabetes mellitus (NIDDM) even in the absence of coronary heart disease or hypertension. The… Expand
Effectiveness of endopeptidase inhibition (candoxatril) in congestive heart failure.
Candoxatril is a novel, orally active inhibitor of neutral endopeptidase EC 18.104.22.168, the enzyme that degrades atrial natriuretic peptide (ANP). The acute and chronic (10 days treatment) hemodynamic… Expand
Evaluation of plasma natriuretic peptides as markers for left ventricular dysfunction.
To test the hypothesis that elevated plasma levels of natriuretic peptides may serve to identify patients with left ventricular (LV) dysfunction, we assessed the predictive diagnostic value of… Expand
Differential effects of growth hormone on cardiomyocyte and extracellular matrix protein remodeling following experimental myocardial infarction.
- D. Grimm, Douglas Cameron, D. Griese, G. Riegger, E. Kromer
- Cardiovascular research
- 1 November 1998
OBJECTIVES Growth hormone (GH) causes cardiomyocyte hypertrophy without development of fibrosis in the normal rat heart. The aim of this study was to evaluate the effects of GH on cardiac remodeling… Expand
Blockade of the renin-angiotensin system in cardiac pressure-overload hypertrophy in rats.
Left ventricular hypertrophy in response to pressure overload may be modified by neurohumoral activation. To investigate the contribution of the renin-angiotensin system, we studied rats after… Expand
Acute hemodynamic interaction of aspirin and ticlopidine with enalapril: results of a double-blind, randomized comparative trial.
BACKGROUND Coprescription of aspirin and ACE inhibitors is frequent in heart failure caused by coronary artery disease. Negative interaction between aspirin and enalapril has been reported,… Expand
Calcitonin Gene‐Related Peptide is Chemotactic for Human T Lymphocytes
- C. A. Foster, B. Mandák, E. Kromer, A. Rot
- Medicine, Biology
- Annals of the New York Academy of Sciences
- 1 June 1992
Certain neuropeptides, such as CGRP, are associated with C-type nerve fibers in the skin and are known to be proinflammatory mediators. Because of their probable role in various cutaneous diseases,… Expand
Recombinant hirudin (HBW 023) prevents troponin T release after coronary angioplasty in patients with unstable angina.
- H. J. Rupprecht, W. Terres, +7 authors J. Meyer
- Journal of the American College of Cardiology
- 1 December 1995
OBJECTIVES This study was performed to evaluate the efficacy of peri-interventional treatment with recombinant hirudin (r-hirudin [HBW 023]) compared with heparin in the prevention of troponin T… Expand