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Development of heart failure following isoproterenol administration in the rat: role of the renin-angiotensin system.
OBJECTIVE High dosages of catecholamines induce cardiomyocyte necrosis and interstitial fibrosis in rats. We investigated whether this initial damage is followed by the development of heart failureExpand
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31P Magnetic Resonance Spectroscopy in Dilated Cardiomyopathy and Coronary Artery Disease: Altered Cardiac High‐Energy Phosphate Metabolism in Heart Failure
BackgroundThe purpose of this work was to further define the value of cardiac 31P magnetic resonance (MR) spectroscopy for patients with coronary artery disease and dilated cardiomyopathy. MethodsExpand
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Myocardial hypertrophy and enhanced left ventricular contractility in Zucker diabetic fatty rats.
Heart failure is known to be a complication of insulin-dependent (IDDM) and noninsulin-dependent diabetes mellitus (NIDDM) even in the absence of coronary heart disease or hypertension. TheExpand
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Effectiveness of endopeptidase inhibition (candoxatril) in congestive heart failure.
Candoxatril is a novel, orally active inhibitor of neutral endopeptidase EC 3.4.24.11, the enzyme that degrades atrial natriuretic peptide (ANP). The acute and chronic (10 days treatment) hemodynamicExpand
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Evaluation of plasma natriuretic peptides as markers for left ventricular dysfunction.
To test the hypothesis that elevated plasma levels of natriuretic peptides may serve to identify patients with left ventricular (LV) dysfunction, we assessed the predictive diagnostic value ofExpand
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Differential effects of growth hormone on cardiomyocyte and extracellular matrix protein remodeling following experimental myocardial infarction.
OBJECTIVES Growth hormone (GH) causes cardiomyocyte hypertrophy without development of fibrosis in the normal rat heart. The aim of this study was to evaluate the effects of GH on cardiac remodelingExpand
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Blockade of the renin-angiotensin system in cardiac pressure-overload hypertrophy in rats.
Left ventricular hypertrophy in response to pressure overload may be modified by neurohumoral activation. To investigate the contribution of the renin-angiotensin system, we studied rats afterExpand
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Acute hemodynamic interaction of aspirin and ticlopidine with enalapril: results of a double-blind, randomized comparative trial.
BACKGROUND Coprescription of aspirin and ACE inhibitors is frequent in heart failure caused by coronary artery disease. Negative interaction between aspirin and enalapril has been reported,Expand
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Calcitonin Gene‐Related Peptide is Chemotactic for Human T Lymphocytes
Certain neuropeptides, such as CGRP, are associated with C-type nerve fibers in the skin and are known to be proinflammatory mediators. Because of their probable role in various cutaneous diseases,Expand
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Recombinant hirudin (HBW 023) prevents troponin T release after coronary angioplasty in patients with unstable angina.
OBJECTIVES This study was performed to evaluate the efficacy of peri-interventional treatment with recombinant hirudin (r-hirudin [HBW 023]) compared with heparin in the prevention of troponin TExpand
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