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Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin
In a rat model of context-induced relapse to heroin, we identified sparsely distributed ventral medial prefrontal cortex (mPFC) neurons that were activated by the heroin-associated context. SelectiveExpand
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Role of ventral medial prefrontal cortex in incubation of cocaine craving
Cue-induced drug-seeking in rodents progressively increases after withdrawal from cocaine, suggesting that cue-induced cocaine craving incubates over time. Here, we explored the role of the medialExpand
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New technologies for examining the role of neuronal ensembles in drug addiction and fear
Correlational data suggest that learned associations are encoded within neuronal ensembles. However, it has been difficult to prove that neuronal ensembles mediate learned behaviours becauseExpand
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Targeted disruption of cocaine-activated accumbens neurons prevents context-specific sensitization
Learned associations between effects of abused drugs and the drug administration environment are important in drug addiction. Histochemical and electrophysiological studies suggest that theseExpand
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Silent synapses in selectively activated nucleus accumbens neurons following cocaine-sensitization
Cocaine-induced alterations in synaptic glutamate function in nucleus accumbens are thought to mediate drug-related behaviors such as psychomotor sensitization. However, previous studies haveExpand
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Context‐specific sensitization of cocaine‐induced locomotor activity and associated neuronal ensembles in rat nucleus accumbens
Repeated cocaine administration to rats outside their home cage induces behavioral sensitization that is strongly modulated by the drug administration environment. We hypothesized that stimuli in theExpand
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New technologies for examining neuronal ensembles in drug addiction and fear
Correlational data suggest that learned associations are encoded within neuronal ensembles. However, it has been difficult to prove that neuronal ensembles mediate learned behaviours becauseExpand
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Context‐specific modulation of cocaine‐induced locomotor sensitization and ERK and CREB phosphorylation in the rat nucleus accumbens
Learned associations are hypothesized to develop between drug effects and contextual stimuli during repeated drug administration to produce context‐specific sensitization that is expressed only inExpand
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References and Notes
the effects of the retrieval-extinction manipulation on fear memories (38), whereas infra-limbic plasticity is critical for maintenance of aversive and appetitive extinction memories (44, 45). In theExpand
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Cocaine and Synaptic Alterations in the Nucleus Accumbens
In the 1990’s, the laboratory of Frank White found decreased excitability of accumbens medium spiny neurons following short withdrawal (3d) from repeated cocaine injections [1] and long-lastingExpand
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