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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.
Recently, significant advances have been made in elucidating the details of the pathways through which signals are transmitted to the NF-kappa B:I kappa B complex in the cytosol and their implications for the study of NF-Kappa B.
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.
Inhibition of NF-kappa B by sodium salicylate and aspirin.
The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-kappa B, which further explains the mechanism of action of these drugs.
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.
It is suggested that processing of MEKK-1 is required for its function in the Toll/IL-1 pathway and an important role for ECSIT in signaling to NF-kappaB is indicated.
Recognition of microbial infection by Toll-like receptors.
Transcriptional Activation of the Cyclooxygenase-2 Gene in Endotoxin-treated RAW 264.7 Macrophages*
- D. Wadleigh, S. Reddy, E. Kopp, S. Ghosh, H. Herschman
- BiologyThe Journal of Biological Chemistry
- 3 March 2000
Cyclooxygenase-2 (COX-2), the enzyme primarily responsible for induced prostaglandin synthesis, is an immediate early gene induced by endotoxin in macrophages. We investigated the cis-acting elements…
The Toll-receptor family and control of innate immunity.
NF-kappa B and rel proteins in innate immunity.
Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity.